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首页> 外文期刊>American journal of rhinology >Hemostatic effect of tranexamic acid in elective nasal surgery.
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Hemostatic effect of tranexamic acid in elective nasal surgery.

机译：氨甲环酸在选择性鼻腔手术中的止血作用。

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BACKGROUND: Bleeding is the most frequent complication of nasal surgery. The aim of this prospective study was to evaluate the effectiveness of tranexamic acid (TA), an antifibrinolytic agent, in reducing bleeding during and after nasal surgery. METHODS: The study sample included 400 patients aged 18-60 years who underwent combination functional endoscopic sinus surgery with septoplasty and conchotomy. Two hundred patients were not given a hemostatic agent (control group) and 200 patients were administered 1 g of oral TA three times daily starting 2 hours before surgery, for 5 days. Bleeding was monitored during surgery and for 2 weeks postoperatively. RESULTS: Patients given oral TA showed significantly less operative and postoperative bleeding compared with controls. No patients required additional packing, compared with five patients in the control group. Adverse reactions to TA were minimal, and they disappeared when the treatment stopped. CONCLUSION: TA is a safe and effective drugfor the reduction of bleeding in nasal surgery. It may be recommendedfor routine use.
机译：背景：出血是鼻外科手术中最常见的并发症。这项前瞻性研究的目的是评估抗纤溶剂氨甲环酸（TA）在减少鼻腔手术期间和之后出血的有效性。方法：研究样本包括400名年龄在18-60岁的患者，他们接受了功能性内窥镜鼻窦手术联合隔膜成形术和结膜切开术。 200例患者未给予止血药（对照组），200例患者在手术前2小时开始每天3次每天1g口服TA，持续5天。在手术期间和术后2周监测出血情况。结果：口服TA的患者与对照组相比，术中和术后出血明显减少。与对照组的五名患者相比，没有患者需要额外的包装。对TA的不良反应极少，并且在治疗停止后消失。结论：TA是减少鼻腔手术出血的安全有效的药物。可能建议常规使用。

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