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首页> 外文期刊>Bulletin of experimental biology and medicine >fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images
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fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images

机译：FMRI对健康个体的反应和轻度抑郁症的患者呈现愉快和令人不愉快的图像

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摘要

Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into "pleasant" and "unpleasant" subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the motor regions (precentral and postcentral gyrus) and in the cerebellum (p 0.05 with FWE correction). Most likely, these clusters are associated with motion (pressing a button in accordance with the instruction). According to the data of intergroup contrasts, patients with depression had less pronounced activation of frontal structures (middle frontal gyrus and other areas, including the white matter) in response to both positive and negative images (p 0.001). In healthy subjects, the response of the temporo-occipital areas (lingual and fusiform gyrus) to unpleasant stimuli was more intensive than in patients (p 0.001). This can be due to differences in the semantic image processing. Thus, in case of mild depression, the response of the amygdaloid complex, the key structure in the development in affective disorder, was not always observed. At the same time, the response of frontal and temporo-occipital regions has a certain potential as a biomarker of mild depression, although the reliability of the obtained data requires additional confirmation.
机译：患有轻度抑郁症和显然健康个体的患者被提出了图像，并要求将它们分类为“愉快”和“令人不快的”子集。在这两组中，脑激活模式之间的主要差异在呈现令人愉悦和令人不愉快的图像期间局部地在电机区（前列腺和后复陀螺）和小脑中（P <0.05以FWE校正）定位在本地中。最有可能的是，这些集群与运动相关联（按照指令按下按钮）。根据杂项对比的数据，抑郁患者响应于正和负图像（P <0.001），抑郁患者的前结构激活在健康受试者中，Temporto-incipital区域（舌苔和纺锤形）对令人不愉快的刺激的反应比患者更加强烈（P <0.001）。这可能是由于语义图像处理的差异。因此，在轻度抑郁症的情况下，杏仁醇复合物的响应，并不总是观察到情感紊乱的开发中的关键结构。同时，正面和颞枕区的响应具有一定的潜力作为温和凹陷的生物标志物，尽管所获得的数据的可靠性需要额外的确认。

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