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首页> 外文期刊>Andrology >Increased risk of organic erectile dysfunction in patients with chronic fatigue syndrome: a nationwide population-based cohort study
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Increased risk of organic erectile dysfunction in patients with chronic fatigue syndrome: a nationwide population-based cohort study

机译：慢性疲劳综合征患者发生器质性勃起功能障碍的风险增加：一项基于全国人群的队列研究

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Chronic fatigue syndrome (CFS) is a complex disorder characterized by profound and persistent fatigue and several comorbidities. CFS was previously reported to be associated with female sexual dysfunction. We propose that CFS might also be associated with organic erectile dysfunction (organic ED). We conducted a retrospective cohort study by using data from the National Health Insurance (NHI) Research Database. We identified 2156 male patients who were newly diagnosed with CFS between January 1, 2003 and December 31, 2006. After excluding those younger than 20years and prevalent cases, 1976 patients were subjected to analysis, and 7904 people served as healthy controls. All study subjects were followed up from the index date to the date of organic ED diagnosis, withdrawal from the NHI program, or the end of 2011. Compared with the non-CFS cohort, the incidence density rate of organic ED was 1.88-fold higher than that in the CFS cohort (3.23 vs. 1.73 per 1000 person-years) with an adjusted hazard ratio (HR) of 1.88 (95% CI=1.26-2.81) when adjusting for sex and comorbidities. The combined impacts of patients with CFS and cardiovascular disease (CVD), diabetes mellitus (DM), chronic kidney disease (CKD), depression, and anxiety showed a significant by joint association with organic ED risk compared with patients with no CFS and no counterpart comorbidity. The greatest magnitude of adjusted HR of ED for CFS was observed in individuals without any comorbidity (3.87, 1.95-7.66). The incidence of organic ED is higher among males aged 40years and over for both CFS and non-CFS cohorts. As the number of comorbidity increases, the incidence of organic ED increases in males without CFS. Higher incidence of organic ED was observed in males with CVD, DM, CKD, depression, or anxiety for both CFS and non-CFS cohorts.
机译：慢性疲劳综合症（CFS）是一种复杂的疾病，其特征是严重的持续性疲劳和多种合并症。先前报道CFS与女性性功能障碍有关。我们建议CFS也可能与器质性勃起功能障碍（有机ED）有关。我们使用国家健康保险（NHI）研究数据库中的数据进行了回顾性队列研究。我们确定了2003年1月1日至2006年12月31日期间新诊断为CFS的2156例男性患者。在排除20岁以下和流行病例之后，对1976例患者进行了分析，并有7904例作为健康对照。从索引日期到进行有机ED诊断，退出NHI计划或2011年底为止，对所有研究对象进行了随访。与非CFS队列相比，有机ED的发生密度比高1.88倍。相比于CFS队列（每千人年3.23比1.73），调整性别和合并症时的调整后风险比（HR）为1.88（95％CI = 1.26-2.81）。与无CFS和无对应CFS的患者相比，CFS和心血管疾病（CVD），糖尿病（DM），慢性肾脏病（CKD），抑郁症和焦虑症患者的综合影响通过联合与器质性ED风险显着相关合并症。在没有任何合并症的人群中观察到CFS ED的最大调整后HR幅度最大（3.87，1.95-7.66）。 CFS和非CFS人群中40岁及以上的男性有机物ED的发生率更高。随着合并症数量的增加，在没有CFS的男性中有机ED的发生率增加。在CFS和非CFS人群中，患有CVD，DM，CKD，抑郁或焦虑的男性中有机ED的发生率较高。

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