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首页> 外文期刊>American Journal of Physiology >Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?
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Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?

机译：心血管健康膳食硝酸盐补充剂：一种助剂或运动治疗？

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Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which can be converted to nitric oxide in low oxygen conditions. The associated beneficial physiological effects include a reduction in blood pressure, modification of platelet aggregation, and increases in limb blood flow. There have been numerous studies of nitrate supplementation in healthy recreational and competitive athletes; however, the ergogenic benefits are currently unclear due to a variety of factors including small sample sizes, different dosing regimens, variable nitrate conversion rates, the heterogeneity of participants' initial fitness levels, and the types of exercise tests used. In clinical populations, the study results seem more promising, particularly in patients with cardiovascular diseases who typically present with disruptions in the ability to transport oxygen from the atmosphere to working tissues and reduced exercise tolerance. Many of these disease-related, physiological maladaptations, including endothelial dysfunction, increased reactive oxygen species, reduced tissue perfusion, and muscle mitochondrial dysfunction, have been previously identified as potential targets for nitric oxide restorative effects. This review is the first of its kind to outline the current evidence for inorganic nitrate supplementation as a therapeutic intervention to restore exercise tolerance and improve quality of life in patients with cardiovascular diseases. We summarize the factors that appear to limit or maximize its effectiveness and present a case for why it may be more effective in patients with cardiovascular disease than as ergogenic aid in healthy populations.
机译：已经显示出绿叶蔬菜和根部丰富的无机硝酸盐的口服消耗量增加循环等离子体亚硝酸盐浓度，其可以在低氧气条件下转化为一氧化氮。相关的有益生理效应包括降低血压，改性血小板聚集，并增加肢体血流。在健康的娱乐和竞争运动员中有许多研究核糖补充;然而，由于各种因素，包括小样本尺寸，不同的给药方案，可变硝酸盐转化率，参与者初始适应性水平的异质性以及所使用的运动试验的类型，因此源于各种因素，因此源于各种因素，以及所使用的运动试验的类型，以及使用的各种因素，以及所使用的运动试验的类型。在临床群体中，研究结果似乎更有前景，特别是在患有通常存在中断的心血管疾病的患者中，该患者通常存在于从大气中运送到工作组织的氧气和减少运动耐受性的能力。这些疾病相关的许多生理治疗过程中，包括内皮功能障碍，增加的反应性氧物质，减少的组织灌注和肌肉线粒体功能障碍，已经先前被鉴定为潜在的一氧化氮恢复效应。本综述是首先概述无机硝酸盐补充剂作为治疗干预的现有证据，以恢复耐受心血管疾病患者的运动耐受性和提高生活质量。我们总结了似乎限制或最大化其有效性的因素，并提出了为什么在心血管疾病患者中可能更有效的情况，而不是在健康种群中的良好助剂。

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