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Bidirectional interactions between curcumin and gut microbiota in transgenic mice with Alzheimer's disease

机译：阿尔茨海默病的转基因小鼠姜黄素和肠道微生物之间的双向相互作用

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Alzheimer's disease (AD) is a neurodegenerative disease with increasing prevalence worldwide, while there are no effective drugs at present. Curcumin, a natural polyphenolic substance isolated from turmeric, is a promising natural compound to combat AD, but its pharmacology remains to be fully understood for its poor in vivo bioavalibility. Inspired by the recently reported associations between gut microbiota and AD development, the present study investigated the interactions of curcumin with gut microbiota of APP/PS1 double transgenic mice from two directions: (i) curcumin influences gut microbiota, and (ii) gut microbiota biotransform curcumin. It was found that curcumin administration tended to improve the spatial learning and memory abilities and reduce the amyloid plaque burden in the hippocampus of APP/PS1 mice. On the one hand, curcumin administration altered significantly the relative abundances of bacterial taxa such as Bacteroidaceae, Prevotellaceae, Lactobacillaceae, and Rikenellaceae at family level, and Prevotella, Bacteroides, and Parabacteroides at genus level, several of which have been reported to be key bacterial species associated with AD development. On the other hand, a total of 8 metabolites of curcumin biotransformed by gut microbiota of AD mice through reduction, demethoxylation, demethylation and hydroxylation were identified by HPLC-Q-TOF/MS, and many of these metabolites have been reported to exhibit neuroprotective ability. The findings provided useful clues to understand the pharmacology of curcumin and microbiome-targeting therapies for AD.
机译：阿尔茨海默病的疾病（AD）是一种神经变性疾病，普遍存在普遍存在，而目前没有有效的药物。姜黄素是从姜黄中分离的天然多酚物质，是对抗广告的有希望的天然化合物，但其药理学仍然被全面的体内生物可爱性差。受到肠道微生物群和广告开发之间最近报告的协会的启发，本研究研究了姜黄素与来自两个方向的APP / PS1双转基因小鼠的肠道微生物的相互作用：（i）姜黄素影响肠道微生物，和（ii）肠道微生物肿瘤生物转移姜黄素。发现姜黄素给药倾向于改善空间学习和记忆能力，并降低APP / PS1小鼠海马的淀粉样蛋白斑块负担。一方面，姜黄素给药显着改变了细菌分类的相对丰富，如菌斑，PREVOTECEAE，乳杆菌和家庭水平的牛麸菌，菌菌，诱导菌和在属级别的Paramactodes，其中几种据报道是关键的细菌与广告开发相关的物种。另一方面，通过HPLC-Q-TOF / MS鉴定了通过还原，去甲氧化，去甲基化和羟基化的AD小鼠肠道微生物的8种姜黄素生物转化物的8种代谢物，并据报告许多这些代谢物表现出神经保护能力。该研究结果提供了了解AD的姜黄素和微生物组靶向疗法的药理学的有用线索。

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