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首页> 外文期刊>Applied Microbiology and Biotechnology >Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-gamma- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin
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Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-gamma- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin

机译：来自浅通风口芽孢杆菌菌株APA的多γ-谷氨酸的抗疱疹病毒1和免疫调节活性

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摘要

Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for novel antiviral compounds, including those of natural origin. In this study, the recently described poly-gamma-glutamic acid (gamma-PGA-APA), produced by the marine thermotolerant Bacillus horneckiae strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties. The biopolymer hindered the HSV-1 infection in the very early phase of virus replication. In addition, the gamma-PGA-APA was shown to exert low cytotoxicity and noticeable immunomodulatory activities towards TNF-alpha and IL-1 beta gene expression. Moreover, the capacity to positively modulate the transcriptional activity of the cytokine genes was paired with increased level of activation of the transcription factor NF-kappa B by gamma-PGA-APA. Overall, as non-cytotoxic biopolymer able to contribute in the antiviral defense against HSV-1, gamma-PGA-APA could lead to the development of novel natural drugs for alternative therapies.
机译：单纯疱疹病毒类型1（HSV-1）是通过世界的人类的常见和广泛的病毒感染负责，中枢神经系统中的罕见但极度严重，临床综合征。在使用中，抗性菌株的出现促进了寻找新的抗病毒化合物，包括天然来源的化合物。在该研究中，通过船舶热调节杆菌菌株APA产生的最近描述的多γ-谷氨酸（γ-PGA-APA），并以其抗HSV-1评价具有生物和抗病毒活性的。和免疫调节性质。生物聚合物在病毒复制的早期阶段受到HSV-1感染。此外，显示γ-PGA-APA向TNF-α和IL-1β基因表达施加低细胞毒性和显着的免疫调节活性。此外，对细胞因子基因的转录活性的能力与γ-PGA-APA的转录因子NF-Kappa B的活化水平增加。总体而言，由于非细胞毒性生物聚合物能够在对HSV-1的抗病毒防御中产生贡献，因此Gamma-PGA-APA可能导致新型天然药物的替代疗法的发展。

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