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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Significance of Circulating Galectin-3 in Patients with Pancreatobiliary Cancer
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Significance of Circulating Galectin-3 in Patients with Pancreatobiliary Cancer

机译：循环半乳糖素-3在胰腺癌患者中的意义

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摘要

Background/Aim: Pancreatobiliary cancer is a disease associated with a dismal prognosis and limited treatment options. The aim of the present study was to clarify the usefulness of circulating galectin-3 in pancreatobiliary cancer. Patients and Methods: We examined serum galectin3 concentrations in 45 patients with pancreatobiliary cancer. Receiver operating characteristic curves were utilized to evaluate the accuracy of circulating galectin-3 to discriminate pancreatobiliary cancer patients from controls and predict the prognostic outcomes. Results: Circulating galectin-3 had diagnostic value at the cut-off level of 6.2 ng/ml, and the patients' overall survival was predictable at the cut-off level of 10.3 ng/ml. Furthermore, circulating galectin-3 >= 10.3 ng/ml was an independent prognostic marker in pancreatobiliary cancer. Regarding biliary cancer, higher galectin-3 was associated with malnutrition. On the other hand, regarding pancreatic cancer, higher galectin-3 levels were associated with higher inflammatory parameters. Conclusion: Galectin-3 can be a useful biomarker in patients with pancreatobiliary cancer.
机译：背景/目的：胰腺癌是一种与令人沮丧的预后和有限的治疗方案相关的疾病。本研究的目的是阐明在胰腺癌中循环半乳糖蛋白-3的有用性。患者和方法：我们在45例胰腺癌患者中检查了血清Galectin3浓度。接收器操作特征曲线用于评估循环Galectin-3的准确性，以鉴别来自对照的胰腺癌患者并预测预后结果。结果：循环Galectin-3在截止水平为6.2ng / ml的截止水平上具有诊断值，患者的整体存活率在10.3ng / ml的截止水平上可预测。此外，循环半乳糖凝集素-3> = 10.3ng / ml是胰腺癌中的独立预后标志物。关于胆道癌，高愈合蛋白-3与营养不良有关。另一方面，关于胰腺癌，较高的Galectin-3水平与更高的炎症参数有关。结论：Galectin-3可以是胰腺癌患者的有用生物标志物。

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