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首页> 外文期刊>Prevention science: the official journal of the Society for Prevention Research >Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation
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Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

机译：预防早期物质使用介质，以及SLC6A4调节的变化，SAAF干预对OXTR甲基化的影响

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Abstract The Strong African American Family (SAAF) program has been shown to have a variety of short and long-term benefits for participating youth and families. However, biological mechanisms potentially influencing long-term effects on resilience in young adulthood have not been examined. In the current investigation, we examine the effects of SAAF on methylation of the OXTR gene in young adulthood, focusing on a regulatory region previously identified to be both responsive to stress and implicated in resilience. Using the subsample of participants from the original study for whom methylation data was available ( N = 388), we replicated the previously reported G 鼸 effect on prevention of early substance use and then examined whether there would also be a moderated effect on OXTR methylation in early adulthood, with s allele carriers, but not LL participants, showing a significant indirect effect of SAAF on OXTR methylation. Results suggest that for susceptible youth (i.e., s allele carriers), preventive intervention may get under the skin, in a manner potentially beneficial for long-term outcomes. Implications for examination of OXTR methylation in future prevention research are discussed.
机译：摘要“强大的非裔美国人家庭”（SAAF）计划已被证明对参与的年轻人和家庭有各种短期和长期的好处。然而，尚未研究可能影响年轻成年人恢复力长期效应的生物学机制。在目前的研究中，我们研究了SAAF对年轻成年人OXTR基因甲基化的影响，重点关注一个先前被确定为既对压力有反应又与恢复力有关的调控区域。使用原始研究中有甲基化数据的参与者的子样本（N=388），我们复制了之前报告的G鼸 研究了s等位基因携带者（而非LL参与者）在成年早期对OXTR甲基化是否也有调节作用，表明SAAF对OXTR甲基化有显著的间接影响。结果表明，对于易感青年（即s等位基因携带者），预防性干预可能会深入到皮肤下，以一种可能有益于长期结果的方式进行。讨论了OXTR甲基化检测在未来预防研究中的意义。

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