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首页> 外文期刊>Journal of biochemical and molecular toxicology >Investigation of oxidant/antioxidant and anti-inflammatory effects of apigenin on apoptosis in sepsis-induced rat lung
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Investigation of oxidant/antioxidant and anti-inflammatory effects of apigenin on apoptosis in sepsis-induced rat lung

机译：对甲虫诱导大鼠肺细胞凋亡的氧化剂/抗氧化剂和抗炎作用的研究

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We suppose that apigenin may inhibit the cellular process of sepsis-induced lung injury, which is considered to be a major cause of morbidity and mortality, and may improve inflammation and oxidative stress. The aim of this study was to investigate the potential protective effect of apigenin in a rat model of polymicrobial sepsis. Eight groups consisting of a total of 64 female Wistar albino rats were used for this study. Pro-inflammatory (TNF-α, IL-1-β, IL-6) and anti-inflammatory (TGF-β, IL-10) cytokine levels were measured with the enzyme-linked immunosorbent assay technique, oxidant/antioxidants parameters were measured using the spectrophotometric method and Bax and Caspase-3 immunohistochemical methods. TNF-α, TGF-β, IL-1β, and IL-6 levels significantly increased in the sepsis-induced group than in the control groups, while IL-10 levels decreased. Lipid peroxidase (LPO), an oxidative stress marker, increased, while the antioxidant defense parameters of superoxide dismutase (SOD), catalase (CAT) activities, glutathione (GSH) levels decreased. Although Bax and Caspase-3 immunoreactivity and H score levels significantly increased in the sepsis group, significant decreases were found in the groups treated with apigenin. In conclusion, we are of the opinion that apigenin treatment improves lung injury by inhibiting oxidative stress and inflammatory cell damage.
机译：我们认为芹菜素可能抑制脓毒症引起的肺损伤的细胞过程，这被认为是发病率和死亡率的主要原因，并可能改善炎症和氧化应激。本研究的目的是研究芹菜素在多微生物败血症大鼠模型中的潜在保护作用。本研究使用了8组共64只雌性Wistar白化大鼠。促炎（TNF-α、IL-1-β、IL-6）和抗炎（TGF-β、IL-10）细胞因子水平采用酶联免疫吸附试验技术测定，氧化剂/抗氧化剂参数采用分光光度法和Bax和Caspase-3免疫组化方法测定。脓毒症诱导组的TNF-α、TGF-β、IL-1β和IL-6水平显著高于对照组，而IL-10水平下降。氧化应激标志物脂质过氧化物酶（LPO）升高，而超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活性和谷胱甘肽（GSH）水平的抗氧化防御参数降低。虽然败血症组的Bax和Caspase-3免疫反应性和H评分显著升高，但芹菜素治疗组的Bax和Caspase-3免疫反应性和H评分显著降低。总之，我们认为芹菜素治疗通过抑制氧化应激和炎症细胞损伤改善肺损伤。

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