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首页> 外文期刊>Annual review of chemical and biomolecular engineering >Advances in Bioactive Hydrogels to Probe and Direct Cell Fate
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Advances in Bioactive Hydrogels to Probe and Direct Cell Fate

机译：生物活性水凝胶探测和指导细胞命运的研究进展

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摘要

Advanced cell culture techniques are increasingly needed to better understand basic cell physiology, predict in vivo response, and engineer dc novo functional tissue substitutes. Toward this concept, hydrogels have emerged as biomimetic in vitro culture systems that allow cells to be grown in or on user-defined microenvironments that recapitulate many critical aspects of native tissue. Hydrogel biofunctionality can be engineered predictably and precisely via the tailorability of the hydrogel's chemical and mechanical properties, each of which directly influences cell fate. In this review, we highlight state-of-the-art hydrogel platforms that have been used to assay and define cell behavior, placing an emphasis on recent directions in systems that offer dynamic control of material properties in time and space. We review current understanding of cell-material interactions in 2D and discuss recent and future efforts, as well as challenges, in extending this work to 3D. Ultimately, advances in hydrogel culture systems, synthetic approaches, and biological assays that can be performed in 3D are providing new opportunities to recapitulate fully the native cell niche.
机译：越来越需要先进的细胞培养技术，以更好地了解基本细胞生理学，预测体内反应并设计dc novo功能性组织替代品。朝着这个概念发展，水凝胶已经成为一种仿生体外培养系统，它可以使细胞在用户定义的微环境中生长，该环境可以概括天然组织的许多关键方面。水凝胶的生物功能性可以通过水凝胶的化学和机械性质的可定制性进行可预测的精确设计，而水凝胶的化学和机械性质中的每一个都会直接影响细胞的命运。在这篇综述中，我们重点介绍了用于检测和定义细胞行为的最新水凝胶平台，重点介绍了可动态控制时间和空间材料特性的系统中的最新方向。我们回顾了当前对2D细胞-材料相互作用的理解，并讨论了将这项工作扩展到3D方面的最新和未来工作以及挑战。最终，可以在3D模式下进行的水凝胶培养系统，合成方法和生物学分析技术的进步为完全概括天然细胞的生态位提供了新的机会。

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