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首页> 外文期刊>Antiviral chemistry & chemotherapy >Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity.
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Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity.

机译：来自红海藻Sebdenia polydactyla的硫酸木糖甘露聚糖：结构特征，化学修饰和抗病毒活性。

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摘要

BACKGROUND: Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy. METHODS: In this study, we analysed polysaccharide fractions isolated from Sebdenia polydactyla. RESULTS: The purified xylomannan sulfate and its further sulfated derivatives showed strong activity against herpes simplex virus type-1 (HSV-1). Their 50% inhibitory concentration values were in the range 0.35-2.8 mug/ml and they lacked cytotoxicity at concentrations up to 1,000 mug/ml. The major polysaccharide, which had 0.6 sulfate groups per monomer unit and an apparent molecular mass of 150 kDa, contained a backbone of alpha-(1-->3)-linked d-mannopyranosyl residues substituted at position 6 with a single stub of beta-d-xylopyranosyl residues. CONCLUSIONS: The degree of sulfation seemed to play an important role because desulfation and/or further sulfation of the isolated macromolecules largely influenced their in vitro anti-HSV-1 activity.
机译：背景：许多病毒显示出对细胞表面硫酸乙酰肝素蛋白聚糖的亲和力，并且与病毒进入具有生物学相关性。这增加了将硫酸化多糖应用于抗病毒治疗的可能性。方法：在这项研究中，我们分析了分离自多毛Sebdenia polydactyla的多糖级分。结果：纯化的木糖甘露聚糖硫酸盐及其进一步的硫酸化衍生物显示出对单纯疱疹病毒1型（HSV-1）的强活性。它们的50％抑制浓度值在0.35-2.8杯/毫升的范围内，当浓度高达1,000杯/毫升时，它们没有细胞毒性。主要的多糖，每个单体单元具有0.6个硫酸盐基团，表观分子量为150 kDa，包含在第6位被一个β单个残基取代的α-（1-> 3）-连接的d-甘露吡喃糖基残基的骨架。 -d-木吡喃糖基残基。结论：硫酸化程度似乎起重要作用，因为分离的大分子的脱硫和/或进一步硫酸化极大地影响了它们的体外抗HSV-1活性。

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