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首页> 外文期刊>Antonie van Leeuwenhoek: Journal of Microbiology and serology >Endophytic Streptomyces in the traditional medicinal plant Arnica montana L.: secondary metabolites and biological activity
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Endophytic Streptomyces in the traditional medicinal plant Arnica montana L.: secondary metabolites and biological activity

机译：传统药用植物山金车中的内生链霉菌：次生代谢产物和生物活性

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摘要

Arnica montana L. is a medical plant of the Asteraceae family and grows preferably on nutrient poor soils in mountainous environments. Such surroundings are known to make plants dependent on symbiosis with other organisms. Up to now only arbuscular mycorrhizal fungi were found to act as endophytic symbiosis partners for A. montana. Here we identified five Streptomyces strains, microorganisms also known to occur as endophytes in plants and to produce a huge variety of active secondary metabolites, as inhabitants of A. montana. The secondary metabolite spectrum of these strains does not contain sesquiterpene lactones, but consists of the glutarimide antibiotics cycloheximide and actiphenol as well as the diketopiperazines cyclo-prolyl-valyl, cyclo-prolyl-isoleucyl, cyclo-prolyl-leucyl and cyclo-prolyl-phenylalanyl. Notably, genome analysis of one strain was performed and indicated a huge genome size with a high number of natural products gene clusters among which genes for cycloheximide production were detected. Only weak activity against the Gram-positive bacterium Staphylococcus aureus was revealed, but the extracts showed a marked cytotoxic activity as well as an antifungal activity against Candida parapsilosis and Fusarium verticillioides. Altogether, our results provide evidence that A. montana and its endophytic Streptomyces benefit from each other by completing their protection against competitors and pathogens and by exchanging plant growth promoting signals with nutrients.
机译：山金车（Arnica montana L.）是菊科的药用植物，优选在山区环境中营养不良的土壤上生长。已知这种环境使植物依赖于与其他生物的共生。到目前为止，仅发现丛枝菌根真菌可作为蒙塔纳菌的内生共生伙伴。在这里，我们确定了五种链霉菌菌株，这些微生物也被称为植物中的内生菌，并产生大量的活性次生代谢产物，作为蒙塔纳土壤杆菌的居民。这些菌株的次生代谢产物谱不包含倍半萜内酯，而是由戊二酰亚胺抗生素环己酰亚胺和Actiphenol以及二酮哌嗪嗪环脯氨酰基-戊基，环脯氨酰基-异亮氨酰基，环脯氨酰基-亮氨酰基和环脯氨酰基-苯丙氨酰基组成。值得注意的是，对一种菌株进行了基因组分析，结果表明基因组规模巨大，具有大量天然产物基因簇，其中检测到了生产环己酰亚胺的基因。仅显示出对革兰氏阳性细菌金黄色葡萄球菌的弱活性，但是提取物显示出显着的细胞毒性活性以及对副念珠菌和小镰刀菌的抗真菌活性。总而言之，我们的结果提供了证据，表明蒙大纳农杆菌及其内生链霉菌可以通过完成对竞争者和病原体的保护，并通过与营养物质交换促进植物生长的信号而相互受益。

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