Vitamin D and Type 2 diabetes mellitus

XuanY.; ZhaoH.-Y.; LiuJ.-M.

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Vitamin D and Type 2 diabetes mellitus

机译：维生素D和2型糖尿病

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Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for Type 2 diabetes mellitus (T2DM). Vitamin D is involved in the pathogenesis of pancreatic β-cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM. Vitamin D can affect the progress of this disease directly through the activation of its own receptor, and indirectly via the regulation of calcium homeostasis. Observational studies have revealed the association between vitamin D deficiency and incident T2DM. More double-blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.

机译：基于增加来自动物和人类的证据研究中,现在被认为是缺乏维生素D2型糖尿病的潜在风险因素(糖尿病)。发病机理的胰腺β细胞功能障碍,胰岛素抵抗,和系统性炎症,条件的发展做出贡献2型糖尿病。疾病直接通过激活的自己的受体,通过间接监管的钙稳态。揭示了维生素D之间的关系缺乏和事件发生2型糖尿病。随机对照研究,探讨补充维生素D对胰岛素的影响敏感性,胰岛素分泌,发生2型糖尿病。

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来源
《Journal of diabetes》 |2013年第3期|261-267|共7页
作者
XuanY.; ZhaoH.-Y.; LiuJ.-M.;
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作者单位

Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University;

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原文格式 PDF
正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
Calcium homeostasis; Prediabetic State; Vitamin DInsulin ResistanceRisk FactorsType 2 Diabetes MellitusVitamin D Deficiency;

机译：钙稳态;前驱糖尿病的状态;维生素2 DInsulin ResistanceRisk FactorsType糖尿病MellitusVitamin D缺乏;

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Vitamin D and Type 2 diabetes mellitus

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