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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Prognostic impact of microsatellite instability in colorectal cancer patients treated with adjuvant FOLFOX.
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Prognostic impact of microsatellite instability in colorectal cancer patients treated with adjuvant FOLFOX.

机译：微卫星不稳定性对接受FOLFOX辅助治疗的大肠癌患者的预后影响。

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BACKGROUND: Colorectal cancer (CRC) patients whose tumours have microsatellite instability (MSI) do not benefit from adjuvant 5-fluorouracil. However, the predictive value of MSI is not known for FOLFOX, now recommended in adjuvant setting. PATIENTS AND METHODS: MSI phenotype was assessed by the pentaplex method. Three-year relapse and disease-free survival (DFS) of patients treated for CRC with FOLFOX 4 in an adjuvant setting were compared according to MSI phenotype. RESULTS: A total of 105 patients (19 MSI, 86 microsatellite stable, MSS) were included. Stage II patients more frequently exhibited MSI (58%) than MSS (21%); (p=0.002). Patients with MSI relapsed significantly less than those with MSS (10.5% vs. 35.0%; p=0.04). DFS was similar for MSI and MSS (p=0.1). In univariate analysis, stage (p=0.0006) and MSI status (p=0.017) were significant predictors of DFS. CONCLUSION: MSI status was associated with significantly fewer relapses and a better prognosis. FOLFOX4 did not alter survival of patients with MSI and can be administered to them.
机译：背景：肿瘤具有微卫星不稳定性（MSI）的结直肠癌（CRC）患者无法从辅助剂5-氟尿嘧啶中获益。但是，FOLFOX尚不知道MSI的预测值，现在推荐在辅助治疗中使用。患者和方法：通过五重体法评估MSI表型。根据MSI表型比较了接受FOLFOX 4辅助治疗的CRC患者的三年复发和无病生存期（DFS）。结果：总共包括105例患者（19例MSI，86例微卫星稳定，MSS）。 II期患者比MSS（21％）更频繁出现MSI（58％）; （p = 0.002）。 MSI患者的复发率显着低于MSS患者（10.5％比35.0％; p = 0.04）。对于MSI和MSS，DFS相似（p = 0.1）。在单变量分析中，阶段（p = 0.0006）和MSI状态（p = 0.017）是DFS的重要预测指标。结论：MSI状态与复发率明显降低和预后较好有关。 FOLFOX4不会改变MSI患者的生存率，可以将其给药。

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