Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.

Besier S; Ludwig A; Zander J; Brade V; Wichelhaus TA

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Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.

机译：金黄色葡萄球菌对利奈唑胺的耐药性：基因剂量效应，稳定性，适应性成本和交叉耐药性。

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Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cross-resistance to quinupristin-dalfopristin and chloramphenicol.

机译：金黄色葡萄球菌对利奈唑胺的耐药性通常与23S rRNA基因突变有关。在这里，我们显示该基因的不同拷贝中单点突变G2576T的积累导致耐药性逐步提高，生物学适应性受损以及对奎奴普丁-达福普汀和氯霉素的交叉耐药性。

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《Antimicrobial agents and chemotherapy.》 |2008年第4期|共3页
作者
Besier S; Ludwig A; Zander J; Brade V; Wichelhaus TA;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Cancer resistance to treatment; Staphylococcus aureus; Assault by stabbing; 葡萄球菌; 金黄色; 基因剂量; 基因;

机译：Cancer resistance to treatment;Staphylococcus aureus;Assault by stabbing;葡萄球菌;金黄色;基因剂量;基因;

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1. Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. [J] . Besier S, Ludwig A, Zander J, Antimicrobial agents and chemotherapy. . 2008,第4期

机译：金黄色葡萄球菌对利奈唑胺的耐药性：基因剂量效应，稳定性，适应性成本和交叉耐药性。
2. Linezolid Resistance in Staphylococcus aureus: Characterization and Stability of Resistant Phenotype. [J] . Pillai SK, Sakoulas G, Wennersten C, The Journal of Infectious Diseases . 2002,第11期

机译：金黄色葡萄球菌对利奈唑胺的耐药性：耐药表型的表征和稳定性。
3. Acquisition of High-Level Mupirocin Resistance and Its Fitness Cost among Methicillin-Resistant Staphylococcus aureus Strains with Low-Level Mupirocin Resistance [J] . Kanokporn Mongkolrattanothai, Lisa Pumfrey, Peggy Mankin, Journal of Clinical Microbiology . 2009,第12期

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4. Staphylococcus aureus Strains Isolated from Bovine Clinical Mastitis in New York State and Italy: Antibiotic-resistance Genes and Genotype Characteristics [C] . Annual Meeting of The National Mastitis Council . 2019

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5. Prevalence of Staphylococcus aureus and Staphylococcus intermedius among pet industry employees and transfer of erm genes from Staphylococcus aureus to Staphylococcus intermedius colonizing healthy people. [D] . Fu, Xing. 2010

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6. Linezolid Resistance in Staphylococcus aureus: Gene Dosage Effect Stability Fitness Costs and Cross-Resistances [O] . Silke Besier, Albrecht Ludwig, Johannes Zander, 2008

机译：金黄色葡萄球菌对利奈唑胺的耐药性：基因剂量效应稳定性适应性成本和交叉耐药性
7. Linezolid Resistance in Staphylococcus aureus: Gene Dosage Effect, Stability, Fitness Costs, and Cross-Resistances▿ [O] . Besier, Silke, Ludwig, Albrecht, Zander, Johannes, 2008

机译：金黄色葡萄球菌对利奈唑胺的耐药性：基因剂量效应，稳定性，适应性成本和交叉耐药性▿

Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.

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