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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei.
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Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei.

机译:针对克氏假丝酵母质量控制分离株的抗真菌组合物的多实验室测试。

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摘要

Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration.
机译:八个实验室使用含有两性霉素B(AMB),泊沙康唑(PSC),卡泊芬净(CSP)和伏立康唑(VRC)的棋盘格成对组合的96孔板,对八个实验室的假丝酵母(Candida krusei)ATCC 6258进行了测试。该方法学导致整个实验室的结果可重复。所有药物组合产生的MIC均低于单独测试的任何两种药物的MIC,通过分数抑制浓度的总和,AMB,PSC,CSP和VRC的组合无差异(无拮抗作用)。

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