Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa.

Davies TA; Shang W; Bush K; Flamm RK

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Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa.

机译：大肠杆菌和铜绿假单胞菌中多瑞培南和比较剂与青霉素结合蛋白的亲和力。

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Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.

机译：肠胃外碳青霉烯多瑞培南对铜绿假单胞菌中的青霉素结合蛋白2（PBP2）和PBP3和大肠杆菌中的PBP2表现出高度亲和力，而主要的PBPs抑制作用会导致细胞死亡。这种PBP亲和力谱与多瑞培南观察到的广谱革兰氏阴性活性相关。

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《Antimicrobial agents and chemotherapy.》 |2008年第4期|共3页
作者
Davies TA; Shang W; Bush K; Flamm RK;
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正文语种 eng
中图分类治疗学;
关键词
Pseudomonas aeruginosa; Escherichia coli; penicillin-binding protein; gram; 假单胞菌; 铜绿; 大肠杆菌;

机译：Pseudomonas aeruginosa;Escherichia coli;penicillin-binding protein;gram;假单胞菌;铜绿;大肠杆菌;

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1. Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. [J] . Davies TA, Shang W, Bush K, Antimicrobial agents and chemotherapy. . 2008,第4期

机译：大肠杆菌和铜绿假单胞菌中多瑞培南和比较剂与青霉素结合蛋白的亲和力。
2. Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. [J] . Davies TA, Page MG, Shang W, Antimicrobial agents and chemotherapy. . 2007,第7期

机译：头孢比浦和比较剂与大肠杆菌，铜绿假单胞菌，金黄色葡萄球菌和肺炎链球菌的青霉素结合蛋白结合。
3. Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. [J] . Moya B, Zamorano L, Juan C, Antimicrobial agents and chemotherapy. . 2010,第9期

机译：新的头孢菌素CXA-101对铜绿假单胞菌青霉素结合蛋白的亲和力。
4. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. [C] . David Medina, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2018

机译：金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌（MRSA），大肠杆菌和铜绿假单胞菌制成的具有抗菌特性的生物硒纳米粒子的合成与表征。
5. A tale of two RlpAs: Studies of cell division in Escherichia coli and Pseudomonas aeruginosa. [D] . Jorgenson, Matthew Allan. 2014

机译：关于两个RlpA的故事：大肠杆菌和铜绿假单胞菌中细胞分裂的研究。
6. Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa [O] . Todd A. Davies, Wenchi Shang, Karen Bush, 2008

机译：多瑞培南和比较剂对大肠杆菌和铜绿假单胞菌青霉素结合蛋白的亲和力
7. Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa▿ [O] . Davies, Todd A., Shang, Wenchi, Bush, Karen, 2008

机译：多瑞培南及其比较剂对大肠杆菌和铜绿假单胞菌中青霉素结合蛋白的亲和力

Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa.

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