Selenium-containing heterocycles: synthesis and pharmacological activities of some new 4-methylquinoline-2(1H) selenone derivatives.

Abdel-Hafez SH; Hussein MA

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Selenium-containing heterocycles: synthesis and pharmacological activities of some new 4-methylquinoline-2(1H) selenone derivatives.

机译：含硒杂环：一些新的4-甲基喹啉-2（1H）硒酮衍生物的合成和药理活性。

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Several selenolo[2,3-b]quinolines and pyrimido[4',5':4,5]selenolo[2,3-b]quinolines were prepared by annulations via reaction of NaSeH with 2-chloro-3-cyano-4-methylquinoline 1 followed by reactions with aromatic aldehydes, cycloalkanones, and acetic anhydride. Spectroscopic (IR, 1H-NMR, and MS) properties of the synthesized compounds are reported. Some selected compounds 5a, 7b, 7c, 8b-d, 9a, 11b, and 11d were investigated for their anti-inflammatory and analgesic activities; in addition, the most active compounds were tested for their ulcerogenicity and acute toxicity. Moreover, some of the test compounds 7c, 9a, 11b, and 11d were screened for their antibacterial and antifungal activities.

机译：通过NaSeH与2-氯-3-氰基-4反应的环化反应制备了几种硒代[2,3-b]喹啉和嘧啶基[4'，5'：4,5]硒代烯[2,3-b]喹啉-甲基喹啉1，然后与芳族醛，环烷酮和乙酸酐反应。报道了合成化合物的光谱性质（IR，1 H-NMR和MS）。研究了某些选定的化合物5a，7b，7c，8b-d，9a，11b和11d的抗炎和镇痛活性;此外，还测试了活性最高的化合物的致溃疡性和急性毒性。此外，筛选了某些测试化合物7c，9a，11b和11d的抗菌和抗真菌活性。

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《Archiv der Pharmazie》 |2008年第4期|共7页
作者
Abdel-Hafez SH; Hussein MA;
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正文语种 eng
中图分类药学;
关键词
4-methylquinoline; Selenium measurement; derivatives; pharmacological;

机译：4-甲基喹啉硒的测定衍生物药理学;

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1. Selenium-containing heterocycles: synthesis and pharmacological activities of some new 4-methylquinoline-2(1H) selenone derivatives. [J] . Abdel-Hafez SH, Hussein MA Archiv der Pharmazie . 2008,第4期

机译：含硒杂环：一些新的4-甲基喹啉-2（1H）硒酮衍生物的合成和药理活性。
2. 3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: synthesis and pharmacology of 1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4- dihydro-5-methoxy-2(1H)-quinolinone and its derivatives. [J] . Oshiro Y, Sakurai Y, Sato S, Journal of Medicinal Chemistry . 2000,第2期

机译：3,4-二氢-2（1H）-喹啉酮作为新型抗抑郁药：1-（3-（4-（3-（3-氯苯基）-1-哌嗪基）丙基）-3,4-二氢-5的合成与药理作用-甲氧基-2（1H）-喹啉酮及其衍生物。
3. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine. Part 3. Synthesis and pharmacological activity of 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazo(1,2-a)imidazoles. [J] . Matosiuk D, Fidecka S, Antkiewicz Michaluk L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2002,第10期

机译：1-芳基-2-亚氨基咪唑烷的新羰基衍生物的合成及其药理活性。第3部分。1-芳基-5,6（1H）二氧代-2,3-二氢咪唑并（1,2-a）咪唑的合成和药理活性。
4. Synthesis and pharmacological activity of Dmt-Tic analogs with highly potent agonist and antagonist/agonist opioid activity [C] . Remo Guerrini, Gianfranco Balboni, Daniela Girolamo Calo, the International Peptide Symposium . 2001

机译：具有高效激动剂和拮抗剂/激动剂阿片类能活性DMT-TIC类似物的合成与药理活性
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. Isoselenocyanates: A Powerful Tool for the Synthesis of Selenium-Containing Heterocycles [O] . Dinesh Ramesh Garud, Mamoru Koketsu, Hideharu Ishihara 2007

机译：异氰酸酯：合成含硒杂环的有力工具
7. Selenium-Containing Heterocycles From Isoselenocyanates: Synthesis of 1,3-Selenazolidine and Perhydro-1,3-selenazine Derivatives. [O] . Geoffroy L. Sommen, Anthony Linden, Heinz Heimgartner 2005

机译：含硒的异氰酸盐的杂环：1,3-硒唑烷和perydro-1,3-硒嗪衍生物的合成。

Selenium-containing heterocycles: synthesis and pharmacological activities of some new 4-methylquinoline-2(1H) selenone derivatives.

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