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首页> 外文期刊>Archives of disease in childhood. Fetal and neonatal edition >Strategies to manage resistant gram-negative organisms in neonates.
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Strategies to manage resistant gram-negative organisms in neonates.

机译：应对新生儿革兰氏阴性菌耐药性的策略。

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摘要

Gram-negative antibiotic resistance is currently of major concern worldwide. In the UK, the prevalence of multi-resistant gram-negative bacteria (MRGNB) is increasing,1 and outbreaks have occurred in neonatal units (NNUs).Up to 12% of neonates undergo a septic screen at birth, and most of them receive empiric antibiotics.2 Around 70% of NNUs use narrow-spectrum penicillin/gentamicin combinations for empiric treatment of neonatal sepsis.3 However, these regimens may not be active against MRGNB. Vergnano et al found that Enterobacteriaceae accounted for around 20% to 35% of early- and late-onset sepsis, respectively, underlining the threat that MRGNB pose in neonatology. Unlike many other antibiotic-resistant bacteria, MRGNB occur in the community as well as in hospitals, meaning that there is a growing risk of mother-to-baby transmission of MRGNB. This could lead to infected babies being inadequately treated with standard antibiotics, and asymptomati-cally colonised babies could act as a source of transmission to other babies.
机译：革兰氏阴性抗生素抗性目前是全世界主要关注的问题。在英国，多重耐药性革兰氏阴性菌（MRGNB）的患病率呈上升趋势，1新生儿单位（NNU）发生了暴发。高达12％的新生儿在出生时接受了败血性筛查，大多数接受经验性抗生素。2大约70％的NNU使用窄谱青霉素/庆大霉素的组合物对新生儿败血症进行经验性治疗。3但是，这些方案可能对MRGNB无效。 Vergnano等人发现肠杆菌科分别占早发和晚发脓毒症的20％至35％，这突显了MRGNB在新生儿医学中的威胁。与许多其他抗药性细菌不同，MRGNB在社区和医院中都存在，这意味着MRGNB母婴传播的风险越来越高。这可能导致受感染的婴儿未充分接受标准抗生素的治疗，而无症状定殖的婴儿可能成为传染给其他婴儿的来源。

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