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首页> 外文期刊>Annals of Human Genetics >Gene-gene interaction between FGF20 and MAOB in Parkinson disease.
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Gene-gene interaction between FGF20 and MAOB in Parkinson disease.

机译：帕金森病中FGF20和MAOB之间的基因-基因相互作用。

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The fibroblast growth factor 20 (FGF20) and monoamine oxidase B (MAOB) genes are associated with Parkinson Disease (PD) risk and both are in the dopamine bio-pathway. Therefore, we investigated the joint effect between polymorphisms in the FGF20 and MAOB genes for evidence of interaction contributing to PD risk. Fourteen polymorphisms (eight for FGF20, six for MAOB) were genotyped in 736 families and analyzed using conditional logistic regression (CLR). Significant two-locus interactions were found in females between the polymorphisms rs1721100 of FGF20 and rs1799836 of MAOB, and between the polymorphisms rs1721082 of FGF20 and rs1799836 of MAOB. The risk alleles for each SNP identified from CLR, rs1721100 C, rs1721082 T and rs1799836 A, are consistent with previous reports. Using indicator variables for the SNP genotypes, rs1721100 GC with rs1799836 AA showed significant interaction (P = 0.021), compared with the reference group rs1721100 GG with rs1799836 GG. Using an allele-dose model for the risk alleles, rs1721100 and rs1799836 showed significant interaction (P = 0.019). We found similar interaction results between rs1721082 and rs1799836. In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
机译：成纤维细胞生长因子20（FGF20）和单胺氧化酶B（MAOB）基因与帕金森氏病（PD）风险相关，并且都在多巴胺生物途径中。因此，我们研究了FGF20和MAOB基因多态性之间的联合作用，以寻找相互作用导致PD风险的证据。在736个家族中对14个多态性（FGF20为8个，MAOB为6个）进行基因分型，并使用条件逻辑回归（CLR）进行了分析。在雌性中，FGF20的rs1721100多态性与MAOB的rs1799836之间以及FGF20的rs1721082多态性与MAOB的rs1799836之间存在显着的两基因座相互作用。从CLR，rs1721100 C，rs1721082 T和rs1799836 A鉴定出的每个SNP的风险等位基因与以前的报告一致。使用具有SNP基因型的指标变量，与参比组rs172100 GG和rs1799836 GG相比，具有rs1799836 AA的rs1721100 GC表现出显着的相互作用（P = 0.021）。使用风险等位基因的等位基因剂量模型，rs1721100和rs1799836显示出显着的相互作用（P = 0.019）。我们在rs1​​721082和rs1799836之间发现了相似的交互结果。总之，FGF20和MAOB中的变体显示出统计相互作用的证据，这强调了在PD的遗传分析中共同考虑它们的重要性，并说明了导致PD风险的生物相互作用的潜在模式。

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