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The Effects of Curcumin on Aflatoxin B1-Induced Toxicity in Rats

机译：姜黄素对黄曲霉毒素B1致大鼠毒性的影响

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摘要

To evaluate the potential of curcumin on toxic and carcinogenic effects of Aflatoxin B1 (AFB1) in relation to AFB1 metabolism, we studied the effects of curcumin on hepatic AFB1-DNA adduct formation and glutathione S-transferase (GST) activity, and the toxic effects of AFB1 in male Fischer 344 rats. Oral administration of curcumin to 5-week-old male rats at a dose of 8 or 80 mg/kg for five consecutive days for three weeks resulted in reduction of AFB1-DNA adduct formation mediated by both liver microsomal and postmitochondrial fractions. The activity of liver GST toward a universal substrate, CDNB, was increased in curcumin-administered rats. As for the acute toxicity of AFB1, curcumin was orally administered to rats for 3 weeks and then AFB1 was given by intragastric intubation. The result showed a decrease of plasma AST and ALT activities in curcumin-treated rats compared with those which received AFB1 alone. Moreover, we have observed that curcumin also reduced glutathione S-transferase placental form positive single cells and foci caused by AFB1 treatment. These results demonstrate the potential of curcumin to reduce the toxic and carcinogenic effects of AFB1 by modulating hepatic drug metabolizing enzymes responsible for AFB1 metabolism.
机译：为了评估姜黄素对黄曲霉毒素B1（AFB1）与AFB1代谢有关的毒性和致癌作用的潜力，我们研究了姜黄素对肝AFB1-DNA加合物形成和谷胱甘肽S-转移酶（GST）活性的影响以及毒性作用Fischer 344大鼠的AFB1的表达。以5或80 mg / kg的剂量连续5天连续5天给5周龄雄性大鼠口服姜黄素，导致肝微粒体和线粒体后级分介导的AFB1-DNA加合物的形成减少。姜黄素给药的大鼠肝GST对通用底物CDNB的活性增加。至于AFB1的急性毒性，将姜黄素口服给予大鼠3周，然后通过胃内插管给予AFB1。结果表明，与单独接受AFB1的大鼠相比，用姜黄素治疗的大鼠血浆AST和ALT活性降低。此外，我们已经观察到姜黄素还减少了由AFB1处理引起的谷胱甘肽S-转移酶胎盘形成阳性单细胞和病灶。这些结果表明姜黄素通过调节负责AFB1代谢的肝药物代谢酶来降低AFB1的毒性和致癌作用的潜力。

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