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首页> 外文期刊>Biocontrol Science >Synthesis and antimicrobial characteristics of N,N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide)
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Synthesis and antimicrobial characteristics of N,N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide)

机译：N，N'-六亚甲基双（4-氨基甲酰基-1-癸基溴化吡啶鎓）的合成及抗菌特性

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摘要

A bis-quaternary ammonium compound (bis-QAC), N,N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide) (D-38), which has 6 carbon atoms in the connecting methylene chain and 10 carbon atoms in the N-alkyl chain, was synthesized and characterized. D-38 exhibited a wide-ranging and effective antimicrobial action against both bacteria and fungi, compared with those of typical bactericides, such as benzyldodecyldimethylammonium chloride (BAC) and cetylpyridinium chloride (CPC), or popularly-used fungicides, such as 2-(4-thiazolyl) benzimidazole (TBZ) and 1,2-benzisothiazol-3-one (BIT). D-38 showed a high bactericidal activity in the ranges of pH 5 to 8.5, and 10 to 40 deg C, in contrast to mono-QAC, N-dodecylpyridinium iodide (P-12), and the activity of D-38 was little influenced by pH and temperature. Furthermore, urethane sheets containing D-38 were prepared for practical use, and the antibacterial and antifungal efficiency was evaluated. Tests on the antibacterial efficiency of the D-38 sheets were carried out against two strains of bacteria (Staphylococcus aureus IFO 12732, Escherichia coli IFO 3972) according to the film covering method. Additionally, tests on the fungus resistance of the sample were performed by using the mixed spore suspension (Aspergillus niger IFO 6341, Penicillium citrinum IFO 6352, Rhizopus oryzae IFO 31005, Cladosporium cladosporioides IFO 6348, Chaetomium globosum IFO 6347). The growth of both bacteria and fungi was inhibited on sheets containing D-38.
机译：双季铵化合物（bis-QAC），N，N'-六亚甲基双（4-氨基甲酰基-1-癸基溴化吡啶鎓）（D-38），在连接的亚甲基链中有6个碳原子，在连接的亚甲基中有10个碳原子合成并表征了N-烷基链。与典型的杀菌剂（例如苄基十二烷基二甲基氯化铵（BAC）和鲸蜡基吡啶鎓氯化物（CPC）或常用的杀菌剂，例如2-（）相比，D-38对细菌和真菌均具有广泛而有效的抗菌作用。 4-噻唑基）苯并咪唑（TBZ）和1,2-苯并噻唑-3（BIT）。与单QAC，N-十二烷基碘化碘化物（P-12）相比，D-38在pH 5至8.5和10至40℃范围内显示出高杀菌活性，并且D-38的活性很小受pH和温度的影响。此外，制备了含有D-38的聚氨酯片材以供实际使用，并且评估了其抗菌和抗真菌效率。根据膜覆盖方法，对两种细菌（金黄色葡萄球菌IFO 12732，大肠杆菌IFO 3972）进行D-38片材的抗菌效率测试。另外，通过使用混合的孢子悬浮液（黑曲霉IFO 6341，柠檬青霉IFO 6352，米根霉IFO 31005，Cladosporium cladosporioides IFO 6348，球壳球藻IFO 6347）对样品的真菌抗性进行测试。含有D-38的薄片上细菌和真菌的生长均受到抑制。

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