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首页> 外文期刊>International journal of antimicrobial agents >Species-independent pharmacodynamics of gemifloxacin and ciprofloxacin with Haemophilus influenzae and Moraxella catarrhalis in an in vitro dynamic model
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Species-independent pharmacodynamics of gemifloxacin and ciprofloxacin with Haemophilus influenzae and Moraxella catarrhalis in an in vitro dynamic model

机译：吉非沙星和环丙沙星与流感嗜血杆菌和卡他莫拉菌在体外动力学模型中的物种非依赖性药效学

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To demonstrate the antimicrobial effects of the different pharmacokinetics of gemifloxacin and ciprofloxacin, the pharmacodynamics of gemifloxacin and ciprofloxacin were studied using two clinical isolates each of Haemophilus influenzae and Moraxella catarrhalis. Monoexponentially decreasing concentrations of gemifloxacin (single dose, half-life 7.4 h) and ciprofloxacin (two 12-h doses, half-life 4 h) were simulated in an in vitro dynamic model over 8-fold ranges of the area under the curve (AUC)-to-MIC ratio: from 56 to 466 and 112-932 h, respectively. With each quinolone, log-linear relationships were established between the intensity of the antimicrobial effect (I-E) and AUC/MIC. The I-E-log AUC/MIC plots were bacterial strain- and species-independent and the gemifloxacin and ciprofloxacin plots were not superimposable. To generalize the findings obtained with the studied organisms, the effects of gemifloxacin and ciprofloxacin on hypothetical strains of H. influenzae and M. catarrhalis with MICs equal to the respective MIC(90)s were predicted. Based on these predictions, the AUC/MIC(90)s of 320 mg gemifloxacin (800 h with H. influenzae and 400 h with M. catarrhalis) may be 31-34% more efficient than those of 2 x 500 mg ciprofloxacin (730 and 365 h, respectively). These data suggest greater efficacy of gemifloxacin against H. influenzae and M. catarrhalis relative to ciprofloxacin at clinically achievable AUC/MIC ratios. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved. [References: 24]
机译：为了证明吉非沙星和环丙沙星的不同药代动力学的抗微生物作用，使用两种流感嗜血杆菌和卡他莫拉菌的临床分离株研究了吉非沙星和环丙沙星的药效学。在体外动态模型中，在曲线下面积的8倍范围内，模拟了吉非沙星（单剂量，半衰期7.4小时）和环丙沙星（两次12小时剂量，半衰期4小时）的浓度呈单指数下降的趋势（ AUC与MIC的比率：分别为56至466和112-932小时。对于每个喹诺酮，在抗菌作用强度（I-E）和AUC / MIC之间建立了对数线性关系。 I-E-log AUC / MIC图与细菌菌株和物种无关，吉非沙星和环丙沙星图不可重叠。为了概括所研究生物的发现，预测了吉非沙星和环丙沙星对假设的H.感冒株和卡他莫拉氏菌的MIC分别等于MIC（90）。根据这些预测，320 mg吉非沙星的AUC / MIC（90）（流感嗜血杆菌800小时，卡他莫拉菌400 h）的效率可能比2 x 500 mg环丙沙星的AUC / MIC（90）效率高31-34％（730）和365小时）。这些数据表明吉非沙星在临床上可达到的AUC / MIC比值下相对于环丙沙星具有更高的抗流感嗜血杆菌和卡他莫拉氏菌的功效。 （C）2002 Elsevier Science B.V.和国际化学疗法学会。版权所有。 [参考：24]

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