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首页> 外文期刊>British journal of ophthalmology >Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjogren's syndrome patients.
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Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjogren's syndrome patients.

机译：透明质酸钠不同渗透压的眼药水，用于治疗干燥综合征的干眼症。

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Aim: To study the effect of the treatment of dry eye in Sjogren's syndrome patients with hypotonic or isotonic hyaluronate eye drops. METHODS: 40 Sjogren's syndrome patients were divided in two groups and treated as follows: group 1 with hypotonic (150 mOsm/l) 0.4% hyaluronate eye drops; group 2 with isotonic 0.4% hyaluronate eye drops. The eye drops were instilled six times a day for 90 days. Grading of subjective symptoms, break up time (BUT), corneal fluorescein staining, conjunctival rose bengal staining, Schirmer's I test, and conjunctival impression cytology were carried out at 0 and 15, 30, 90 days from the beginning of the study. Patients were examined in a blind fashion. For the statistical analysis the Student's t test, Mann-Whitney U test, and chi(2) test were performed. RESULTS: Symptoms were statistically significantly improved at day 15 in both groups but group 1 patients had a global score statistically significantly better group 2 (p=0.02). At day 15 group 1 patients had an improvement from baseline values of BUT (p=0.003), fluorescein, and rose bengal score (p=0.000001 and p=0.0004 respectively). Group 2 patients had, at day 15, an improvement of BUT and fluorescein score compared to baseline values (p=0.05 and p=0.0001 respectively). A comparison between the two groups showed better results for group 1 patients at day 15 for rose bengal stain (p=0.01) and for BUT (p=0.05) and fluorescein score (p=0.0003) at day 90. The conjunctival impression cytology showed that group 1 had a statistically significant better total score than group 2 starting from day 15 and lasting throughout the study (p<0.02). Also group 2 patients showed an improvement from baseline values starting from day 30 (p=0.000005). CONCLUSION: Hyaluronate eye drops are useful for treating severe dry eye in Sjogren's syndrome patients. The use of a formulation with pronounced hypotonicity showed better effects on corneoconjunctival epithelium than the isotonic solution.
机译：目的：研究干燥性低渗或等渗透明质酸滴眼液对干燥综合征患者干眼症的治疗作用。方法：将40例干燥综合征患者分为两组，按以下方法治疗：第1组低渗（150 mOsm / l）0.4％透明质酸滴眼液;第2组使用等渗的0.4％透明质酸盐眼药水。滴眼液一天六次，共90天。在研究开始后的0、15、30、90天进行主观症状分级，分手时间（BUT），角膜荧光素染色，结膜玫瑰红染色，Schirmer's I检验和结膜印象细胞学检查。对患者进行了盲目检查。为了进行统计分析，执行了学生t检验，Mann-Whitney U检验和chi（2）检验。结果：两组的症状在第15天都有统计学上的显着改善，但第1组的总体得分在统计学上比第2组好（p = 0.02）。第15天，第1组患者的BUT（p = 0.003），荧光素和孟加拉玫瑰评分（分别为p = 0.000001和p = 0.0004）的基线值有所改善。与基线值相比，第2组患者在第15天的BUT和荧光素评分有所改善（分别为p = 0.05和p = 0.0001）。两组之间的比较显示，第1天第90天第1组患者玫瑰红染色（p = 0.01）和BUT（p = 0.05）和荧光素评分（p = 0.0003）的结果更好。结膜印象细胞学检查显示从第15天开始一直持续到整个研究期间，第1组的总得分在统计学上优于第2组（p <0.02）。另外，第2组患者从第30天开始显示相对于基线值有所改善（p = 0.000005）。结论：透明质酸滴眼液可用于治疗干燥综合征的严重干眼症。与等渗溶液相比，使用具有明显低渗性的制剂对角膜结膜上皮显示出更好的效果。

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