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首页> 外文期刊>International journal of clinical pharmacology and therapeutics >Co- and multimedication in users of ASA and vitamin E drugs in the Federal Republic of Germany. Results of the Federal Health Surveys 1984-1999.
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Co- and multimedication in users of ASA and vitamin E drugs in the Federal Republic of Germany. Results of the Federal Health Surveys 1984-1999.

机译：德意志联邦共和国ASA和维生素E药物使用者的联合和多重药物治疗。 1984-1999年联邦健康调查的结果。

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OBJECTIVE: Because ASA- and vitamin E-drugs belong to the most used OTC-medications and adverse drug reactions are depending on the quantity and type of comedication we describe the pattern of usage for ASA- and vitamin E-drugs along with the total drug consumption in Germany. STUDY POPULATION, MATERIAL AND METHODS: Study participants (n = 22.560) were screened in five German health surveys (1984-1999). Total drug usage was monitored with a standardized questionnaire. Blood and serum samples were examined for clinical chemistry and hematological data as well as for selected active substances of drugs. The tocopherols and salicylic acid as the main metabolite of ASA were measured by HPLC in serum samples. RESULTS: The incidence of OTC-drug usage is high in our population. The salicylic acid concentration in the serum samples depends clearly on the reason of usage and remains fairly stable for analgesic use but decreases steadily from 1984 to 1999 for use as antiplatelet drug due to formulations with lower amount of ASA/tablet. The serum concentration of alpha-tocopherol was steadily increasing in users of vitamin E-drugs as well as in no-drug-users. CONCLUSION: Because the frequency of comedication is very high, the risk of adverse drug reactions seems to be a problem that should be considered more seriously by physicians.
机译：目的：由于ASA和维生素E药物属于最常用的OTC药物，药物不良反应取决于喜剧的数量和类型，因此我们描述了ASA和维生素E药物的使用方式以及总药物在德国消费。研究人群，材料和方法：在五项德国健康调查（1984-1999年）中筛选了研究参与者（n = 22.560）。用标准化问卷调查药物的总使用量。检查血液和血清样本的临床化学和血液学数据，以及选定的药物活性物质。通过HPLC测定血清样品中的生育酚和水杨酸作为ASA的主要代谢产物。结果：在我们的人群中，使用非处方药的发生率很高。血清样品中的水杨酸浓度显然取决于使用原因，并且对于止痛药使用保持相当稳定，但由于ASA /片剂含量较低，从1984年至1999年用作抗血小板药物的剂量一直稳定下降。维生素E药物使用者和非药物使用者的血清α-生育酚浓度都在稳定增加。结论：由于喜剧的发生频率很高，因此药物不良反应的风险似乎是一个问题，应由医生予以认真考虑。

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