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首页> 外文期刊>International journal of clinical rheumatology. >Milnacipran, a serotonin and norepinephrine reuptake inhibitor: a novel treatment for fibromyalgia
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Milnacipran, a serotonin and norepinephrine reuptake inhibitor: a novel treatment for fibromyalgia

机译：Milnacipran，5-羟色胺和去甲肾上腺素再摄取抑制剂：纤维肌痛的新型治疗

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Milnacipran hydrochloride is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor that was recently approved by the US FDA for the treatment of fibromyalgia (FM). Evidence has accumulated suggesting that, in animal models, milnacipran may exert pain-mitigating influences involving norepinephrine- and serotonin-related processes at supraspinal, spinal and peripheral levels in pain transmission. Milnacipran has demonstrated efficacy for the reduction of pain as well as improvements in global assessments of well-being and functional capacity among treated FM patients. Its role in addressing comorbidities associated with FM, including visceral pain and migraine, has, as yet, to be investigated. Milnacipran may be of special interest for use in patients for whom hepatic dysfunction precludes the use of other agents, for example, duloxetine. It has a negligible influence on cytochrome metabolism, and therefore may be of particular benefit in patients requiring multiple concurrently prescribed medications. Milnacipran may comprise a reasonable option in the armamentarium of treatments available to manage FM.
机译：盐酸米那普仑是5-羟色胺（5-HT）和去甲肾上腺素（NE）的再摄取抑制剂，最近已被美国FDA批准用于治疗纤维肌痛（FM）。已有证据表明，在动物模型中，米那普仑可能在疼痛传递的脊髓上，脊髓和外周水平施加减轻疼痛的影响，涉及去甲肾上腺素和5-羟色胺相关的过程。 Milnacipran已证明在治疗的FM患者中具有减轻疼痛以及改善健康和功能能力的整体评估的功效。它在解决与FM相关的合并症中的作用，包括内脏疼痛和偏头痛，目前尚待研究。对于肝功能不全而无法使用其他药物（例如度洛西汀）的患者，米那普仑可能特别感兴趣。它对细胞色素代谢的影响可忽略不计，因此在需要同时使用多种处方药的患者中可能特别有益。在可用于管理FM的治疗方法中，Mi​​lnacipran可能是一个合理的选择。

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