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Smoking accounts for more than one third of severe rheumatoid arthritis cases

机译：吸烟占严重类风湿关节炎病例的三分之一以上

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摘要

Results published in the Annals of the Rheumatic Diseases have suggested that smoking is a major risk factor associated with severe rheumatoid arthritis (RA) and is responsible for over one third of cases. Furthermore, patients who are genetically susceptible to the disease are at even greater risk, with over half of cases attributable to smoking. Previous studies have shown that smoking and genetic factors interact to increase the risk of RA, but little is known on how smoking contributes to the disease in the context of genetic variability and what proportion of RA cases are caused by smoking. This latest study, carried out at the Institute of Environmental Medicine, Karolinska Institutet (Stockholm, Sweden), investigated the association between the amount of smoking and the risk of RA, in the context of different HLA-DRB1 shared epitope alleles and tried to quantify the proportion of RA cases caused by smoking.
机译：发表在《风湿病年鉴》上的结果表明，吸烟是与严重类风湿性关节炎（RA）相关的主要危险因素，占三分之一以上。此外，遗传上易患该病的患者处于更大的风险中，一半以上的病例归因于吸烟。先前的研究表明，吸烟和遗传因素相互作用会增加患RA的风险，但在遗传变异性背景下吸烟如何导致疾病以及由吸烟引起的RA病例的比例知之甚少。这项最新的研究是在Karolinska研究所（瑞典斯德哥尔摩）的环境医学研究所进行的，研究了在不同HLA-DRB1共有表位等位基因的背景下吸烟量与RA风险之间的关系，并试图量化吸烟引起的RA病例比例。

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