• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Experimental Pathology >Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
【24h】

Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.

机译：带有Kazal基序和基质金属蛋白酶-14的诱导还原的富含半胱氨酸的蛋白在神经母细胞瘤中的表达及其在肿瘤转移中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neuroblastoma is the most common malignant tumour in infancy; the reversion-inducing cysteine-rich protein with Kazal motifs gene (RECK) is a tumour suppressor gene. Previous studies show that RECK inhibits tumour invasion and metastasis through negative regulation of the matrix metalloproteinase (MMP)-2, MMP-9 and MMP-14. Therefore, we wanted to detect the expression of RECK and MMP-14 in neuroblastomas to assess the correlation between the expression levels of these proteins, and to investigate the roles in the metastasis and development of the tumour. PV-6000 immunohistochemistry method was used to detect the expression levels of RECK and MMP-14 in 36 samples of neuroblastoma tissue. Samples from paraffin wax-embedded specimens and the complete clinicopathological data of 36 neuroblastoma and 10 ganglioneuroma patients were collected. The rate of expression of the RECK protein in the neuroblastoma was low (16.7%). Furthermore, it reduced with the increase in the invasive depth and distant metastasis (P = 0.015; P < 0.05). The rate of expression of the MMP-14 protein in the neuroblastoma was high (58.3%) and increased with the increase in the extent of invasive depth and distant metastasis (P = 0.002; P < 0.05). The expression of the RECK protein correlated negatively with that of MMP-14 (r = -0.418; P < 0.05). Low levels of the RECK protein are expressed in the neuroblastoma, while the MMP-14 protein is expressed at high levels. The RECK and MMP-14 proteins may serve as markers in the estimation of the extent of metastasis and dissemination of the neuroblastoma.
机译：神经母细胞瘤是婴儿期最常见的恶性肿瘤。具有Kazal基序基因（RECK）的诱导回复的富含半胱氨酸的蛋白是抑癌基因。先前的研究表明，RECK通过负调节基质金属蛋白酶（MMP）-2，MMP-9和MMP-14抑制肿瘤的侵袭和转移。因此，我们希望检测神经母细胞瘤中RECK和MMP-14的表达，以评估这些蛋白表达水平之间的相关性，并研究其在肿瘤转移和发展中的作用。采用PV-6000免疫组织化学方法检测36例成神经细胞瘤组织中RECK和MMP-14的表达水平。收集了石蜡包埋的标本样本以及36例神经母细胞瘤和10例神经节神经瘤患者的完整临床病理数据。 RECK蛋白在神经母细胞瘤中的表达率较低（16.7％）。此外，它随着浸润深度和远处转移的增加而减少（P = 0.015; P <0.05）。 MMP-14蛋白在神经母细胞瘤中的表达率较高（58.3％），并且随着浸润深度和远处转移程度的增加而增加（P = 0.002; P <0.05）。 RECK蛋白的表达与MMP-14呈负相关（r = -0.418; P <0.05）。低表达的RECK蛋白在神经母细胞瘤中表达，而MMP-14蛋白则以高水平表达。 RECK和MMP-14蛋白可作为评估神经母细胞瘤转移和扩散程度的标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号