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首页> 外文期刊>International journal of fertility and women's medicine >Hyperinsulinemia does not influence androgens/estrogens ratio in patients with polycystic ovarian syndrome.
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Hyperinsulinemia does not influence androgens/estrogens ratio in patients with polycystic ovarian syndrome.

机译：高胰岛素血症不影响多囊卵巢综合征患者的雄激素/雌激素比例。

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OBJECTIVE: The ratio of androgens to estrogens in patients with polycystic ovarian syndrome (PCOS) and controls was evaluated in order to investigate whether hyperinsulinemia might induce hyperandrogenemia by decreasing androgen catabolism. STUDY DESIGN: Forty women were divided into four groups according to the presence of PCOS, insulin resistance, and normal or abnormal body mass index (BMI); each group consisted of 10 women. Group I comprised patients with PCOS, insulin resistance, and abnormal BMI. Group II consisted of patients with PCOS, without insulin resistance, and with normal BMI. Group III consisted of healthy women (controls) with abnormal BMI. Group IV consisted of healthy women with normal BMI. RESULTS: We found that: (1) the mean fasting insulin levels of groups II, III, and IV were significantly lower than those of group I (P < .001); (2) serum testosterone levels were significantly lower in groups III and IV than in group I and II; (3) there were no significant differences in serum estradiol and estrone levels between women of all groups; (4) women of groups III and IV had significantly lower ratios of testosterone to estradiol at time 0 compared to patients of groups I and II. CONCLUSION: Our results support the view that since hyperinsulinemia induces hyperandrogenism, the increase of androgens should not be attributed to the decrease of androgen catabolism.
机译：目的：评估多囊卵巢综合征（PCOS）患者和对照组中雄激素与雌激素的比例，以研究高胰岛素血症是否可通过减少雄激素分解代谢而诱发高雄激素血症。研究设计：根据PCOS的存在，胰岛素抵抗以及正常或异常体重指数（BMI）将40名妇女分为四组。每个小组由10名妇女组成。第一组包括患有PCOS，胰岛素抵抗和BMI异常的患者。第二组由患有PCOS，无胰岛素抵抗和BMI正常的患者组成。第三组由BMI异常的健康女性（对照组）组成。第四组由BMI正常的健康女性组成。结果：我们发现：（1）II，III和IV组的平均空腹胰岛素水平显着低于I组（P <.001）; （2）第三和第四组的血清睾丸激素水平明显低于第一和第二组; （3）各组女性血清雌二醇和雌酮水平无显着差异; （4）与I和II组的患者相比，III和IV组的妇女在0时的睾丸激素与雌二醇的比例明显较低。结论：我们的结果支持以下观点：既然高胰岛素血症会引起雄激素过多，雄激素的增加不应归因于雄激素分解代谢的减少。

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