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首页> 外文期刊>International journal of gynecological cancer: official journal of the International Gynecological Cancer Society >Human papillomavirus testing as an optional screening tool in low-resource settings of Latin America: experience from the Latin American Screening study.
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Human papillomavirus testing as an optional screening tool in low-resource settings of Latin America: experience from the Latin American Screening study.

机译：人类乳头瘤病毒测试作为拉丁美洲低资源环境中的一种可选筛查工具：拉丁美洲筛查研究的经验。

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Hybrid capture II (HC II) test for oncogenic human papillomaviruses (HPV) was carried out in a cohort of 4284 women at their first clinical visit. Overall prevalence of HPV was 17.1%, decreasing with age from 33.9% among women below 20 years to only 11.0% among those older than 41 years. HPV prevalence was significantly higher among current smokers (odds ratio [OR] 1.31; 95% CI 1.1-1.6), in women with two or more lifetime sexual partners (OR = 1.9; 95% CI 1.6-2.4), and those women with two or more sexual partners during the past 12 months prior to examination (OR = 1.6; 95% CI 1.2-2.2). HPV detection increased in parallel with increasing cytologic abnormality, being highest in women with high-grade squamous intraepithelial lesion (P= 0.001). Specificity of the HPV test in detecting histologically confirmed cervical disease was 85% (95% CI 83.9-86.1). Sensitivity of the HPV test in detecting histologic abnormalities increased in parallel with disease severity, ranging from 51.5% for cervical intraepithelial neoplasia (CIN) 1 to 96.5% for CIN 3 and 100.0% for cancer, with respective decline of positive predictive value. These data suggest that HPV testing with HC II assay might be a viable screening tool among this population with relatively high prevalence of cervical disease.
机译：在一组4284名妇女的首次临床就诊中，对致癌性人乳头瘤病毒（HPV）进行了混合捕获II（HC II）测试。 HPV的总体患病率为17.1％，随年龄的增长从20岁以下女性的33.9％降至41岁以上女性的11.0％。在当前吸烟者中，HPV患病率显着更高（优势比[OR] 1.31; 95％CI 1.1-1.6），有两个或多个终生性伴侣的女性（OR = 1.9; 95％CI 1.6-2.4）和那些在检查前的过去12个月内有两个或多个性伴侣（OR = 1.6; 95％CI 1.2-2.2）。 HPV检测随着细胞学异常的增加而增加，在高度鳞状上皮内病变的女性中最高（P = 0.001）。 HPV检测在检测经组织学证实的宫颈疾病的特异性为85％（95％CI 83.9-86.1）。 HPV检测对组织学异常的检测灵敏度与疾病严重程度同时提高，从宫颈上皮内瘤变（CIN）1的51.5％到CIN 3的96.5％，对于癌症的100.0％不等，阳性预测值分别下降。这些数据表明，用HC II检测进行HPV检测可能是该人群中宫颈疾病患病率较高的可行筛查工具。

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