Authors' response: Central toxic keratopathy: A clinical case series

CotinoJ.M.; SurianoM.M.; DeLaCruzAguilóR.; Vila-ArteagaJ.

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Authors' response: Central toxic keratopathy: A clinical case series

机译：作者的回应：中枢性角化病：临床病例系列

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We have read the letter written by Garcia-Gonzalez and Teus about our article 'Central toxic keratopathy: a clinical case series'.We would like to state that in all our cases (which is the second largest series), spontaneous recovery of the hyperopic shift and visual acuity was seen.CTK is an entity already recognised by most ophthalmologists with this name. This term was first coined by Sonmez and Maloney in 2007. However, this entity has received various names, such as central necrosis lamellar imflamation, central lamellar keratitis, central flap necrosis, and the most recent, keratinocyte-induced corneal micro-oedema (KME).As Garcia-Gonzalez and colleagues say in their letter, initially it was thought that the hyperopic shift was due to the loss of stromal tissue in the flap and the bed, but in recent years, articles published by Hau and Allan in 2012, and Thornton and colleagues in 2012, in which confocal microscopy was performed in CTK cases, it is shown that there is a thinning of the corneal stroma with initial keratocyte loss from the stromal bed, and with gradual repopulation over time, therefore, flap amputation, which is not considered as the first choice of treatment in CTK cases.

机译：我们已经阅读了Garcia-Gonzalez和Teus撰写的关于``中毒性角膜病变：临床病例系列''的文章的信，我们谨声明在所有病例中（这是第二大病例），远视的自然恢复CTK是大多数眼科医生已经认可的具有此名称的实体。该术语最早由Sonmez和Maloney于2007年创造。但是，该实体获得了多种名称，例如中央坏死层状炎症，中央层状角膜炎，中央皮瓣坏死，以及最近的角质形成细胞诱导的角膜微水肿（KME）。就像加西亚·冈萨雷斯（Garcia-Gonzalez）及其同事在信中所说的那样，最初人们认为远视移位是由于皮瓣和床中的基质组织损失所致，但近年来，Hau和Allan在2012年发表的文章中，和Thornton及其同事在2012年对CTK病例进行了共聚焦显微镜检查，结果表明，角膜基质变薄，基质层中最初的角膜细胞丢失，随着时间的推移逐渐繁殖，因此皮瓣截肢，这不是CTK病例的首选治疗方法。

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《British journal of ophthalmology》 |2013年第11期|共2页
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CotinoJ.M.; SurianoM.M.; DeLaCruzAguilóR.; Vila-ArteagaJ.;
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1. Authors' response: Central toxic keratopathy: A clinical case series [J] . CotinoJ.M., SurianoM.M., DeLaCruzAguilóR., British journal of ophthalmology . 2013,第11期

机译：作者的回应：中枢性角化病：临床病例系列
2. Central toxic keratopathy: A clinical case series [J] . MaríCotinoJ.F., SurianoM.M., DeLaCruzAguilóR.I., British journal of ophthalmology . 2013,第6期

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Authors' response: Central toxic keratopathy: A clinical case series

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