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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >The effect of high-intensity focused ultrasound treatment on immune function in patients with uterine fibroids
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The effect of high-intensity focused ultrasound treatment on immune function in patients with uterine fibroids

机译：高强度聚焦超声治疗对子宫肌瘤患者免疫功能的影响

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Purpose: The aim of this study was to investigate the effect of high-intensity focused ultrasound (HIFU) on immune function in patients with uterine fibroids, in a randomised comparison to conventional myomectomy. Methods: The patients were assigned (1:1) to the HIFU group or the myomectomy (MY) group. Venous blood samples were collected 24h before and 24h and 72h after operation. The percentages of CD4+ and CD8+ T cells and natural killer (NK) cells were quantified by flow cytometry (FCM). Serum levels of interleukin-2 (IL-2), IL-6 and IL-10 were determined using enzyme-linked immunosorbent assay. Results: HIFU was associated with early ambulation, fewer post-operative complications, and shorter hospital stay (p0.001). The percentages of CD4+ and CD8+ T cells and NK cells in the HIFU group were not significantly altered after treatment compared with before treatment. In contrast, the numbers of these cells in the MY group decreased significantly 24h after conventional myomectomy (p0.001). The CD4 +/CD8+ T cell ratios were also decreased significantly 24h and 72h after conventional myomectomy (p0.001). Serum levels of IL-6 and IL-10 increased after treatment in both groups. Peak IL-6 and IL-10 levels were significantly lower in the HIFU group than in the MY group (p0.001). In contrast, IL-2 level decreased significantly in the MY group compared to the HIFU group at 24h post-operation (p0.001). Conclusions: Short-term post-operative immune function is better preserved after HIFU treatment. Better preserved immune function may reflect a reduction in tissue trauma after HIFU treatment and contribute to reduced post-operative complications.
机译：目的：本研究的目的是与常规子宫肌瘤切除术进行随机比较，研究高强度聚焦超声（HIFU）对子宫肌瘤患者免疫功能的影响。方法：将患者（1：1）分为HIFU组或子宫肌瘤切除术（MY）组。术前，术后24h，术后72h采集静脉血。通过流式细胞术（FCM）定量CD4 +和CD8 + T细胞和自然杀伤（NK）细胞的百分比。使用酶联免疫吸附测定法测定血清白介素2（IL-2），IL-6和IL-10的水平。结果：HIFU与早期移动，术后并发症少和住院时间短有关（p <0.001）。 HIFU组的CD4 +和CD8 + T细胞和NK细胞百分比与治疗前相比无明显变化。相反，常规子宫肌瘤切除术后24h，MY组中这些细胞的数量明显减少（p <0.001）。常规子宫肌瘤切除术后24h和72h，CD4 + / CD8 + T细胞比率也显着降低（p <0.001）。两组治疗后血清IL-6和IL-10水平升高。 HIFU组的IL-6和IL-10峰值水平显着低于MY组（p <0.001）。相比之下，与HIFU组相比，术后24h M​​Y组的IL-2水平显着降低（p <0.001）。结论：HIFU治疗后，短期术后免疫功能得到较好的保留。保留更好的免疫功能可能反映HIFU治疗后组织创伤的减少，并有助于减少术后并发症。

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