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首页> 外文期刊>British journal of ophthalmology >Implications of bevacizumab on vascular endothelial growth factor and endostatin in human choroidal neovascularisation.
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Implications of bevacizumab on vascular endothelial growth factor and endostatin in human choroidal neovascularisation.

机译：贝伐单抗对人脉络膜新血管形成中血管内皮生长因子和内皮抑素的影响。

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摘要

AIM: To evaluate the implications of intravitreal bevacizumab on proangiogenic vascular endothelial growth factor (VEGF) with regard to the endogenous angiogenesis inhibitor endostatin in human choroidal neovascularisation (CNV) secondary to age-related macular degeneration. METHODS: Retrospective review of an interventional case series of 48 patients who underwent full macular translocation surgery with removal of CNV. Twenty-five patients were treated with intravitreal bevacizumab injection 1 to 154 days prior to surgery (bevacizumab CNV). Twenty-three CNV without any kind of previous treatment were used as controls (control CNV). CNV were stained for CD34, cytokeratin18, VEGF, endostatin and E-selectin. A "predominance score of VEGF over endostatin" (PS) was defined by the difference between VEGF and endostatin staining scores. RESULTS: Bevacizumab CNV revealed a weaker VEGF expression in endothelial cells (p = 0.0245) but significantly more intense endostatin in retina pigment epithelium (RPE) (p =0.0001) and stroma (p<0.0001). Consequently, PS was significantly lower in RPE (p = 0.02), vessels (p = 0.03) and stroma (p = 0.0004) in bevacizumab CNV. The intensity of E-selectin expression in bevacizumab CNV was comparable with that in control CNV. CONCLUSIONS: A shift within the angiogenic balance in terms of decreased VEGF predominance over endostatin is detected in human CNV treated with bevacizumab.
机译：目的：评估玻璃体内贝伐单抗对继发于年龄相关性黄斑变性的人脉络膜新生血管（CNV）中的内源性血管生成抑制剂内皮抑素的影响，对促血管新生血管内皮生长因子（VEGF）的影响。方法：回顾性分析了48例行全黄斑移位手术并去除CNV的患者的介入病例系列。 25例患者在手术前1至154天接受玻璃体内贝伐单抗注射治疗（贝伐单抗CNV）。将未经任何治疗的23例CNV用作对照（对照CNV）。 CNV进行CD34，细胞角蛋白18，VEGF，内皮抑素和E-选择素染色。通过VEGF和内皮抑素染色分数之间的差异来定义“ VEGF相对于内皮抑素的优势分数”（PS）。结果：贝伐单抗CNV显示内皮细胞中VEGF表达较弱（p = 0.0245），但视网膜色素上皮（RPE）（p = 0.0001）和基质（p <0.0001）中内皮抑素的强度明显更高。因此，贝伐单抗CNV的RPE（p = 0.02），血管（p = 0.03）和基质（p = 0.0004）的PS显着降低。贝伐单抗CNV中E选择素的表达强度与对照CNV中的E选择素表达强度相当。结论：在用贝伐单抗治疗的人CNV中检测到血管生成平衡发生变化，这是因为血管内皮生长因子的优势超过内皮抑素。

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