• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population
【24h】

TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population

机译：TNFSF4多态性与马来西亚人群的系统性红斑狼疮有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tumour necrosis factor superfamily 4 (TNFSF4) gene has been reported to be associated with systemic lupus erythematosus (SLE) susceptibility due to its encoding for OX40L protein that can increase autoantibody production and cause imbalance of T-cell proliferation. The purpose of this study was to investigate the association of TNFSF4 rs2205960, rs1234315, rs8446748 and rs704840 with SLE in the Malaysian population. A total of 476 patients with SLE and 509 healthy controls were recruited. Real-time polymerase chain reaction (PCR) was applied to genotype the selected single nucleotide polymorphisms (SNPs). Allelic and genotypic frequencies of each SNP were calculated for each ethnic group, and association test was performed using logistic regression. The overall association of each SNP in Malaysian patients with SLE was determined with meta-analysis. The frequency of minor T allele of TNFSF4 rs2205960 was significant in Chinese and Indian patients with SLE, with P values of 0.05 (OR=1.27, 95% CI: 1.00-1.61) and 0.004 (OR=3.16, 95% CI: 1.41-7.05), respectively. Significant association of minor G allele of rs704840 with SLE was also observed in Chinese (P=0.03, OR=1.26, 95% CI: 1.02-1.56). However, after Bonferroni correction, only T allele of rs2205960 remained significantly associated with Indian cohort. Overall, minor G allele of rs704840 showed significant association with SLE in the Malaysian population with P values of 0.05 (OR=1.20, 95% CI: 1.00-1.43). We suggested TNFSF4 rs704840 could be the potential SLE risk factors in the Malaysian population.
机译：据报道，肿瘤坏死因子超家族4（TNFSF4）基因与系统性红斑狼疮（SLE）易感性相关，因为它编码OX40L蛋白，可增加自身抗体的产生并引起T细胞增殖失衡。这项研究的目的是调查马来西亚人口中TNFSF4 rs2205960，rs1234315，rs8446748和rs704840与SLE的关联。总共招募了476名SLE患者和509名健康对照者。应用实时聚合酶链反应（PCR）对选定的单核苷酸多态性（SNP）进行基因分型。计算每个种族的每个SNP的等位基因和基因型频率，并使用逻辑回归进行关联测试。通过荟萃分析确定马来西亚SLE患者中每个SNP的总体关联。在中国和印度的SLE患者中，TNFSF4 rs2205960的次要T等位基因频率较高，P值分别为0.05（OR = 1.27，95％CI：1.00-1.61）和0.004（OR = 3.16，95％CI：1.41-）。 7.05）。在中国人中也观察到rs704840的次要G等位基因与SLE显着相关（P = 0.03，OR = 1.26，95％CI：1.02-1.56）。但是，在Bonferroni校正后，仅rs2205960的T等位基因仍与印度人群显着相关。总体而言，在马来西亚人群中，rs704840的次要G等位基因显示出与SLE显着相关，P值为0.05（OR = 1.20，95％CI：1.00-1.43）。我们建议TNFSF4 rs704840可能是马来西亚人群中潜在的SLE危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号