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首页> 外文期刊>International journal of immunopathology and pharmacology. >The expression of tslp receptor in chronic rhinosinusitis with and without nasal polyps
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The expression of tslp receptor in chronic rhinosinusitis with and without nasal polyps

机译：tslp受体在有鼻息肉和无鼻息肉的慢性鼻-鼻窦炎中的表达

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Chronic Rhinosinusitis with or without Nasal Polyps (CRSwNP and CRSsNP) may be characterized by different cytokine profiles. Generally, Th2 cytokines and eosinophilic infiltration have been reported to be more specific of CRSwNP compared to CRSsNP, where neutrophils seem to play a major role. The epithelial cell-derived thymic stromal lymphopoietin (TSLP) has been recently identified as a key factor in Th2-inflammatory response. The aim of this study is to investigate the expression of TSLP Receptor (TSLP R) in surgical specimens obtained from patients affected by CRSwNP (n=10) and CRSsNP (n = 5) by immunohistochemical techniques (immunostaining score, IS). TSLP R expression was significantly higher in the inflammatory infiltrate and in the epithelial cells of CRSwNP, CRSsNP patients compared to the control group (IS 4.5±0.68, 4.4±1.44 and 0.43±0.3 respectively, p=0.0024 for inflammatory infiltrate and IS 5.8±0.92, 7.8±2.06 and 0.86±0.55 respectively, p=0.0018 for epithelial cells). No significant difference was observed in IS of inflammatory infiltrate and epithelial cells in CRSwNP compared to CRSsNP. Very low IS for TSLP R was found in connective tissue of all the samples, with no difference among the groups. TSLP receptor is highly expressed in CRS compared to controls and independently from the polyps suggesting an early common inflammatory pathway in the two CRS phenotypes.
机译：有或没有鼻息肉的慢性鼻鼻窦炎（CRSwNP和CRSsNP）的特征可能在于细胞因子的不同。通常，据报道，与中性粒细胞起主要作用的CRSsNP相比，Th2细胞因子和嗜酸性粒细胞浸润对CRSwNP更具特异性。上皮细胞源性胸腺基质淋巴细胞生成素（TSLP）最近已被确定为Th2炎症反应的关键因素。这项研究的目的是通过免疫组化技术（免疫染色评分，IS）研究从受CRSwNP（n = 10）和CRSsNP（n = 5）影响的患者获得的手术标本中TSLP受体（TSLP R）的表达。与对照组相比，CRSwNP，CRSsNP患者的炎性浸润和上皮细胞中TSLP R表达明显高于对照组（分别为IS 4.5±0.68、4.4±1.44和0.43±0.3，炎性浸润p = 0.0024，IS 5.8±上皮细胞分别为0.92、7.8±2.06和0.86±0.55，p = 0.0018）。与CRSsNP相比，CRSwNP中炎性浸润和上皮细胞的IS没有观察到显着差异。在所有样品的结缔组织中发现TSLP R的IS极低，各组之间无差异。与对照相比，TSLP受体在CRS中高表达，并且独立于息肉，提示这是两种CRS表型的早期常见炎症途径。

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