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首页> 外文期刊>International Journal of Pharmaceutics >Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
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Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.

机译：化妆品和药用真皮产品中的脂质纳米颗粒（SLN，NLC）。

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摘要

Solid lipid nanoparticles (SLN) are distinguishable from nanostructured lipid carriers (NLC) by the composition of the solid particle matrix. Both are an alternative carrier system to liposomes and emulsions. This review paper focuses on lipid nanoparticles for dermal application. Production of lipid nanoparticles and final products containing lipid nanoparticles is feasible by well-established production methods. SLN and NLC exhibit many features for dermal application of cosmetics and pharmaceutics, i.e. controlled release of actives, drug targeting, occlusion and associated with it penetration enhancement and increase of skin hydration. Due to the production of lipid nanoparticles from physiological and/or biodegradable lipids, this carrier system exhibits an excellent tolerability. The lipid nanoparticles are a "nanosafe" carrier. Furthermore, an overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown.
机译：固体脂质纳米颗粒（SLN）通过固体颗粒基质的组成与纳米结构脂质载体（NLC）有所区别。两者都是脂质体和乳剂的替代载体系统。这篇综述文章集中在用于皮肤应用的脂质纳米颗粒上。脂质纳米颗粒和包含脂质纳米颗粒的最终产物的生产通过成熟的生产方法是可行的。 SLN和NLC在化妆品和药物的皮肤应用中表现出许多功能，即活性成分的控释，药物靶向，闭塞以及与之相关的渗透增强和皮肤水化增加。由于由生理和/或生物可降解脂质产生脂质纳米颗粒，因此该载体系统表现出优异的耐受性。脂质纳米颗粒是“纳米安全”的载体。此外，给出了目前市场上的化妆品的概述，并且示出了局部治疗的益处/风险比的改善。

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