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首页> 外文期刊>International Journal of Pharmaceutics >Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers.
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Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers.

机译：海藻酸盐稳定的超顺磁性氧化铁纳米颗粒：药代动力学，组织分布及其在检测肝癌中的应用。

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The objectives of this study were to describe the pharmacokinetics and tissue distribution of superparamagnetic iron oxide nanoparticle (SPIO) stabilized with alginate (SPIO-alginate), and investigate its potential in detecting liver cancers as a newly developed magnetic resonance (MR) contrast agent. Pharmacokinetics and tissue distribution of SPIO-alginate were investigated in Sprague-Dawley rats. The results showed that SPIO-alginate was eliminated rapidly from serum with the half-life of 0.27h at 109.5mumolFe/kg and accumulated dominantly in liver and spleen with a total percentage of more than 90% of dose after intravenous injection. The studies of pharmacokinetics and distribution of SPIO-alginate in rats indicated the MR contrast agent, based on SPIO, mainly accumulating in targeting organs that contain phagocytosing cells, i.e. liver and spleen. The efficacies in detecting hepatocellular carcinoma (HCC) of rat with primary liver cancer and xenograft liver cancers of rabbit were investigated before and after injection of SPIO-alginate. The signal intensity of liver parenchyma in rabbit with VX2 tumor after injection of SPIO-alginate was reduced sharply resulting in a significant contrast between liver parenchyma and tumor. Detection of the HCC in rat model was also demonstrated. The present study provides evidence that SPIO-alginate might have the ability to improve the detection of liver tumors as an MR contrast agent, and the efficacy is associated with the SPIO specifically located in Kupffer cells in hepatic sinusoid.
机译：这项研究的目的是描述用藻酸盐（SPIO-藻酸盐）稳定的超顺磁性氧化铁纳米粒子（SPIO）的药代动力学和组织分布，并研究其作为新开发的磁共振（MR）造影剂在检测肝癌中的潜力。在Sprague-Dawley大鼠中研究了SPIO-藻酸盐的药代动力学和组织分布。结果表明，SPIO-藻酸盐在109.5μmolFe/ kg时能从血清中迅速清除，半衰期为0.27h，并在肝和脾中占优势，在静脉注射后占总剂量的90％以上。对大鼠SPIO-藻酸盐的药代动力学和分布的研究表明，基于SPIO的MR造影剂主要在含有吞噬细胞的靶器官（即肝脏和脾脏）中蓄积。研究了在注射SPIO-藻酸盐之前和之后检测兔原发性肝癌和异种移植肝癌大鼠肝细胞癌（HCC）的效率。注射SPIO-藻酸盐后，患有VX2肿瘤的兔肝实质的信号强度急剧降低，导致肝实质与肿瘤之间存在明显的对比。还证明了在大鼠模型中检测到HCC。本研究提供证据，SPIO-藻酸盐可能具有改善作为MR造影剂的肝肿瘤检测的能力，并且该功效与SPIO特异地位于肝窦中的Kupffer细胞中有关。

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