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首页> 外文期刊>European journal of pain : >A psychophysical study of endogenous analgesia: the role of the conditioning pain in the induction and magnitude of conditioned pain modulation.
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A psychophysical study of endogenous analgesia: the role of the conditioning pain in the induction and magnitude of conditioned pain modulation.

机译：内源性镇痛的心理生理研究：条件性疼痛在条件性疼痛调节的诱导和幅度中的作用。

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摘要

Endogenous analgesia (EA) can be examined experimentally using a conditioned pain modulation (CPM) paradigm. While noxious conditioning stimulation intensities (CSIs) are mainly used, it has not been fully investigated in the same experimental design whether the experienced conditioning pain level affects CPM responses. The principal goal of the present study was to characterize CPM induction and magnitudes evoked by various conditioning pain levels. Furthermore, we explored associations between conditioning pain reports and CPM responses across various CSIs. Thirty healthy, young, right-handed males were tested with a parallel CPM paradigm. Three different CSIs (hand water-immersion) induced mild, moderate and intense pain levels, rated 12.41 +/- 7.85, 31.57 +/- 9.56 and 58.1 +/- 11.43, respectively (0-100 numerical pain scale) (P < 0.0001). Contact-heat 'test-stimulus' levels were compared before and during conditioning. Within the group, (i) CPM was induced only by the moderate and intense CSIs (Ps
机译：内源性镇痛（EA）可以使用条件性疼痛调节（CPM）范例进行实验检查。虽然主要使用有毒的条件刺激强度（CSIs），但在相同的实验设计中尚未充分研究过有经验的条件疼痛水平是否会影响CPM反应。本研究的主要目标是表征各种条件性疼痛水平引起的CPM诱导和幅度。此外，我们探讨了各种CSI的适应性疼痛报告与CPM反应之间的关联。使用平行的CPM范例对30名健康，年轻，惯用右手的男性进行了测试。三种不同的CSI（手浸入水中）引起的轻度，中度和剧烈疼痛程度分别为12.41 +/- 7.85、31.57 +/- 9.56和58.1 +/- 11.43（0-100数值疼痛量表）（P <0.0001 ）。在调节之前和期间比较接触热的“测试刺激”水平。在该组中，（i）CPM仅由中度和强烈CSI诱导（Ps

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