Peliosis of the spleen with massive recurrent haemorrhagic ascites, despite splenectomy, and associated with elevated levels of vascular endothelial growth factor.

Joseph F; Younis N; Haydon G; Adams DH; Wynne S; Gillet MB; Maurice YM; Lipton ME; Berstock D; Jones IR

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Peliosis of the spleen with massive recurrent haemorrhagic ascites, despite splenectomy, and associated with elevated levels of vascular endothelial growth factor.

机译：尽管进行了脾切除术，脾脏仍伴有大量复发性出血性腹水，并伴有血管内皮生长因子水平升高。

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We present the case of a 33-year-old man with isolated splenic peliosis, a rare pathological condition characterized by blood filled cystic lesions. The patient presented with recurrent massive haemorrhagic ascites, which did not resolve, despite a splenectomy. He was found to have massively elevated levels of vascular endothelial growth factor (VEGF). The clinical course of the disease was prolonged. Repeated blood transfusions for recurrent anaemia were required, in addition to repeated aspiration of reaccumulating haemorrhagic ascites and pleural effusion. The clinical course was not in keeping with previously reported cases. We have described an atypical clinical presentation in a patient with isolated splenic peliosis associated with elevated VEGF concentrations. No previously known associations for the condition were found despite thorough investigations. Management of the patient has been symptomatic and palliative. We have reviewed the various reported associations of peliosis and discussed thepossible role of VEGF in this patient's condition.

机译：我们介绍了一个33岁的男子，患有孤立性脾盂积水的病例，这是一种罕见的病理性疾病，其特征是充满血液的囊性病变。该患者表现出复发性大出血性腹水，尽管脾切除术仍未能解决。发现他的血管内皮生长因子（VEGF）含量大量升高。该疾病的临床病程延长。除了反复抽吸积聚的出血性腹水和胸腔积液外，还需要为输血复发性贫血重复输血。临床过程与先前报道的病例不符。我们已经描述了患有孤立的脾性骨盆病且VEGF浓度升高的患者的非典型临床表现。尽管进行了彻底的调查，但尚未发现与该病有关的先前关联。对患者的治疗一直是症状性和姑息性的。我们已经审查了多种报告的骨质疏松症协会，并讨论了VEGF在该患者病情中的可能作用。

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来源
《European journal of gastroenterology and hepatology》 |2004年第12期|共6页
作者
Joseph F; Younis N; Haydon G; Adams DH; Wynne S; Gillet MB; Maurice YM; Lipton ME; Berstock D; Jones IR;
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正文语种 eng
中图分类内科学;
关键词
Patients; Ascites; bevacizumab; Clinical; 病人; 腹水;

机译：Patients;Ascites;bevacizumab;Clinical;病人;腹水;

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1. Peliosis of the spleen with massive recurrent haemorrhagic ascites, despite splenectomy, and associated with elevated levels of vascular endothelial growth factor. [J] . Joseph F, Younis N, Haydon G, European journal of gastroenterology and hepatology . 2004,第12期

机译：尽管进行了脾切除术，脾脏仍伴有大量复发性出血性腹水，并伴有血管内皮生长因子水平升高。
2. Elevated serum level of IL-33 and sST2 in patients with ankylosing spondylitis: associated with disease activity and vascular endothelial growth factor. [J] . Xiao-lin Li, Tian-tian Lin, Chen-yue Qi, Journal of investigative medicine . 2013,第5期

机译：强直性脊柱炎患者血清IL-33和sST2升高：与疾病活动性和血管内皮生长因子有关。
3. Aortitis syndrome (Takayasu's arteritis) with cataract and elevated serum level of vascular endothelial growth factor. [J] . Harada M, Yoshida H, Mitsuyama K, Scandinavian journal of rheumatology . 1998,第1期

机译：白内障和血清血管内皮生长因子水平升高的主动脉炎综合征（高T动脉炎）。
4. Activation of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) induced angiogenesis under influence of low level laser radiation in vitro [C] . Levon Gasparyan, Grigory Brill, Anu Makela Mechanisms for Low-Light Therapy; Progress in Biomedical Optics and Imaging; vol.7 no.26 . 2006

机译：体外低水平激光照射下血管内皮生长因子（VEGF）和成纤维细胞生长因子（FGF）的激活诱导血管生成
5. Investigations into foldameric inhibitors of protein-protein interactions: Studies of the Bcl-2 family of proteins and vascular endothelial growth factor. [D] . Kaufman, Kimberly Joy. 2010

机译：蛋白质-蛋白质相互作用的折叠抑制剂研究：蛋白质Bcl-2家族和血管内皮生长因子的研究。
6. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. [O] . R. G. Tilton, T. Kawamura, K. C. Chang, 1997

机译：大鼠葡萄糖水平升高引起的血管功能障碍是由血管内皮生长因子介导的。
7. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. [O] . Tilton, R. G., Kawamura, T., Chang, K. C., 1997

机译：大鼠葡萄糖水平升高引起的血管功能障碍是由血管内皮生长因子介导的。

Peliosis of the spleen with massive recurrent haemorrhagic ascites, despite splenectomy, and associated with elevated levels of vascular endothelial growth factor.

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