Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.

Gondela E; Walczak KZ

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Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.

机译：3,4-二氯-5-（ω-羟烷基氨基）-2（5H）-呋喃酮的合成和初步生物活性测定。

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5-(Omega-hydroxyalkylamino) derivatives of mucochloric acids were synthesized through a facile substitution reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid) acetate or 5-methylcarbonate with an appropriate amino alcohol or aminodiol. The obtained products were characterized and screened for their antibacterial and antiprotozoal activities.

机译：通过3,4-二氯-5-羟基-2（5H）-呋喃酮（粘氯酸）乙酸盐或5-甲基碳酸酯与适当的氨基醇的易取代反应，合成了粘氯酸的5-（ω-羟烷基氨基）衍生物。氨基二醇。对获得的产物进行表征并筛选其抗菌和原生动物活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第9期|共5页
作者
Gondela E; Walczak KZ;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones. [J] . Gondela E, Walczak KZ European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第9期

机译：3,4-二氯-5-（ω-羟烷基氨基）-2（5H）-呋喃酮的合成和初步生物活性测定。
2. Synthesis of combinatorial libraries of 3,4,5-trisubstituted 2(5H)-furanones. Part One: Construction of a sub-library of halogenated 5-alkoxy-2(5H)-furanones. [J] . Lattmann E, Billington DC, Langley CA Drug design and discovery . 1999,第3期

机译：3,4,5-三取代的2（5H）-呋喃酮组合库的合成。第一部分：卤代5-烷氧基-2（5H）-呋喃酮子库的构建。
3. Synthesis of combinatorial libraries of 3,4,5-trisubstituted 2(5H)-furanones. Part Two: Construction of a library of 4-amino-5-alkoxy-2(5H)-furanones. [J] . Lattmann E, Billington DC, Langley CA Drug design and discovery . 1999,第3期

机译：3,4,5-三取代的2（5H）-呋喃酮组合库的合成。第二部分：构建4-氨基-5-烷氧基-2（5H）-呋喃酮的文库。
4. Synthesis And Characterization of Bioactive Sol- Gel Glass:A Preliminary Study [C] . Dan Nicolae Ungureanu, Nicolae Angelescu, Adrian Catangiu, International conference on material and manufacturing technology . 2012

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Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.

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