Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists.

Ballart B; Marti J; Velasco D; Lopez Calahorra-F; Pascual J; Luisa Garcia-M; Cabre F; Mauleon D

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists.

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Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists.

机译：新型4-2-（7-杂环甲氧基萘基-2-基甲氧基）乙基苯甲酸作为LTD（4）-拮抗剂的合成及药理评价。

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A group of new 4-[2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethyl]benzoic acids have been synthesized and pharmacologically evaluated as LTD(4)-antagonists. Thiazole derivatives, especially 4-[2-[7-(4-cyclobutylthiazole-2-ylmethoxyl)naphthalen- 2-ylmetho-xy]et hyl]benzoic acid, present considerable activity and improved pharmacokinetic profiles in comparison with our quinoline containing lead molecule confirming the interest of our compounds as potentially oral antiasthmatics and that the 4-alkylthiazole system can be considered as bioisosteric of the quinoline ring at least in our series of compounds.

机译：一组新的4- [2-（7-杂环甲氧基萘基-2-基甲氧基）乙基]苯甲酸已被合成，并在药理上被评价为LTD（4）-拮抗剂。与我们的含喹啉铅分子相比，噻唑衍生物，尤其是4- [2- [7-（4-环丁基噻唑-2-基甲氧基）萘--2-基甲基-xy] et羟基]苯甲酸具有相当大的活性并改善了药物动力学。证实了我们的化合物作为潜在的口服抗哮喘药的兴趣，并且至少在我们的一系列化合物中，4-烷基噻唑系统可以被认为是喹啉环的生物立体异构体。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2000年第4期|共9页
作者
Ballart B; Marti J; Velasco D; Lopez Calahorra-F; Pascual J; Luisa Garcia-M; Cabre F; Mauleon D;
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正文语种 eng
中图分类医药、卫生;
关键词
Benzoic Acids; Leukotriene D4; 苯甲酸类; 白三烯D4;

机译：Benzoic Acids;Leukotriene D4;苯甲酸类;白三烯D4;

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1. Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. [J] . Ballart B, Marti J, Velasco D, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2000,第4期

机译：新型4-2-（7-杂环甲氧基萘基-2-基甲氧基）乙基苯甲酸作为LTD（4）-拮抗剂的合成及药理评价。
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Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists.

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