Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents.

Prakash O; Kumar M; Kumar R; Sharma C; Aneja KR

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Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents.

机译：高价碘（III）介导的新型不对称2,5-二取代的1,3,4-恶二唑类化合物作为抗菌剂和抗真菌剂。

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A series of novel 2,5-disubstituted 1,3,4-oxadiazoles 4 have been conveniently synthesized by oxidative cyclization of pyrazolylaldehyde N-acylhydrazones 3 promoted by iodobenzene diacetate under mild conditions (11 examples, up to 92% isolated yields). All the eleven compounds were tested in vitro for their antibacterial activity against gram-positive bacteria namely, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their inhibitory action against two strains of fungus.

机译：通过在温和条件下由碘代苯二乙酸酯促进的吡唑基醛N-酰基hydr三酮3的氧化环化反应，可以方便地合成一系列新颖的2,5-二取代的1,3,4-恶二唑4（11个实例，分离产率高达92％）。在体外测试了所有11种化合物对革兰氏阳性菌，即金黄色葡萄球菌，枯草芽孢杆菌和两种革兰氏阴性菌，即大肠杆菌和铜绿假单胞菌的抗菌活性。还测试了所有合成的化合物对两种菌株的抑制作用。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第9期|共6页
作者
Prakash O; Kumar M; Kumar R; Sharma C; Aneja KR;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents. [J] . Prakash O, Kumar M, Kumar R, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第9期

机译：高价碘（III）介导的新型不对称2,5-二取代的1,3,4-恶二唑类化合物作为抗菌剂和抗真菌剂。
2. Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. [J] . Sangshetti JN, Chabukswar AR, Shinde DB Bioorganic and Medicinal Chemistry Letters . 2011,第1期

机译：微波辅助一锅合成一些新颖的2,5-二取代的1,3,4-恶二唑类作为抗真菌剂。
3. Recyclable CuO nanoparticles-catalyzed synthesis of novel-2,5-disubstituted 1,3,4-oxadiazoles as antiproliferative, antibacterial, and antifungal agents [J] . M. S. R. Murty, Raju Penthala, Sudheer Kumar Buddana, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2014,第10期

机译：可循环利用的CuO纳米颗粒催化合成新型2,5-二取代的1,3,4-恶二唑类作为抗增殖剂，抗菌剂和抗真菌剂
4. An Efficient Approach to Synthesis of 2,5-Disubstituted-l, 3, 4-oxadiazole Containing Furan Using Microwave Irradiation [C] . Cui Zining, Zhou Xinyu, Li Ying, International Symposium on Pesticide and Environmental Safety . 2007

机译：使用微波辐射合成含有呋喃的2,5-二取代-1,3,4-恶二唑的有效方法
5. I. Sulfonium-mediated oxidative glycosylation of glycal donors for the synthesis of C(2)-hydroxy-beta-glycosides. II. Hypervalent iodine (III)-mediated oxidative glycosylation of glycal donors for the synthesis of C(2)-acyloxy-beta-glycosides. III. Efforts toward the synthesis of immunologic adjuvant QS-21A(api). [D] . Kim, Yong-Jae. 2003

机译：I.硫介导的葡萄糖供体的氧化糖基化反应，用于合成C（2）-羟基-β-糖苷。二。高价碘（III）介导的糖供体的氧化糖基化反应，用于合成C（2）-酰氧基-β-糖苷。三，致力于合成免疫佐剂QS-21A（api）。
6. Convenient Synthesis of 671213-Tetrahydro-5H-Cyclohepta21-b:34-b’diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent [O] . Lei Peng, Xiaofei Zhang, Chunhao Yang 2019

机译：方便的合成由高价碘（III）试剂介导的671213-四氢-5H-环庚基21-b：34-b二吲哚衍生物
7. Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles [O] . -1

机译：Photoredox催化使得具有高效碘（III）试剂的脱羧环化：获得2,5-二取代的1,3,4-二氧化唑

Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents.

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