Synthesis and antiproliferative activity of novel sugiol beta-amino alcohol analogs.

Cordova I; Leon LG; Leon F; San-Andres L; Luis JG; Padron JM

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Synthesis and antiproliferative activity of novel sugiol beta-amino alcohol analogs.

机译：新型sugiolβ-氨基醇类似物的合成及其抗增殖活性。

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摘要

A series of beta-amino alcohol analogs of sugiol were synthesized in a straightforward manner. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573 and WiDr. The most potent analogs induced considerably growth inhibition in the range 1.5-6.7 microM. The results showed that beta-amino alcohol analogs are more potent than the parent compound. In addition, the derivatives with secondary amine fragments showed more active than those bearing tertiary amines.

机译：以简单的方式合成了一系列sugiol的β-氨基醇类似物。在人实体瘤细胞系A2780，SW1573和WiDr中检查了体外抗增殖活性。最有效的类似物在1.5-6.7 microM范围内引起相当大的生长抑制。结果表明，β-氨基醇类似物比母体化合物更有效。此外，具有仲胺片段的衍生物比具有叔胺的衍生物显示出更高的活性。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2006年第11期|共6页
作者
Cordova I; Leon LG; Leon F; San-Andres L; Luis JG; Padron JM;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词
analogs; Alcohols; Synthesis; novel; 醇类;

机译：analogs;Alcohols;Synthesis;novel;醇类;

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1. Synthesis and antiproliferative activity of novel sugiol beta-amino alcohol analogs. [J] . Cordova I, Leon LG, Leon F, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2006,第11期

机译：新型sugiolβ-氨基醇类似物的合成及其抗增殖活性。
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5. Asymmetric synthesis of beta-amino alcohols and enantioselective synthesis of chiral sulfinic esters. [D] . Evans, Jared Wayne. 2004

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6. Chemical synthesis of echistatin a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs. [O] . V M Garsky, P K Lumma, R M Freidinger, 1989

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Synthesis and antiproliferative activity of novel sugiol beta-amino alcohol analogs.

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