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Is the detection of circulating tumor cells in locally advanced pancreatic cancer a useful prognostic marker?

机译：在局部晚期胰腺癌中检测循环肿瘤细胞是否是有用的预后指标？

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Evaluation of: Bidard FC, Huguet F, Louvet C et al. Circulating tumor cells in locally advanced pancreatic adenocarcinoma: the ancillary CirCe 07 study to the LAP 07 trial. Ann. Oncol. 24(8), 2057-2061 (2013). Circulating tumor cells (CTCs) may be shed from the primary tumor and lead to metastatic disease. This evaluated article reports on CTCs in locally advanced pancreatic cancer (LAPC). By assessing CTCs from peripheral blood prior to any treatment and after 2 months of chemotherapy, 11% of patients had detectable CTCs. These patients had a poorer overall survival. With such low numbers of CTCs detected in LAPC patients, it is unclear whether CTCs can actually contribute toward tumor invasiveness and spread in such an aggressive cancer. Although this is a well-designed study, the small number of patients with detectable CTCs means that the statistical power is not great enough to make firm conclusions. Therefore, this expensive assay needs further investigation before being used a prognostic marker in patients with LAPC.
机译：评估：Bidard FC，Huguet F，Louvet C等。在局部晚期胰腺腺癌中循环肿瘤细胞：LAP 07试验的辅助CirCe 07研究。安Oncol。 24（8），2057-2061（2013）。循环肿瘤细胞（CTC）可能会从原发肿瘤中脱落并导致转移性疾病。该评价文章报道了局部晚期胰腺癌（LAPC）中的四氯化碳。通过在任何治疗之前和化疗2个月后评估外周血中的CTC，有11％的患者可检出CTC。这些患者的总生存期较差。由于在LAPC患者中检测到的CTC数量如此之低，目前尚不清楚CTC是否真正有助于这种侵略性癌症中的肿瘤浸润和扩散。尽管这是一项精心设计的研究，但可检测CTC的患者人数很少，这意味着统计能力不足以得出明确的结论。因此，在将这种昂贵的测定用于LAPC患者的预后指标之前，需要进一步研究。

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