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首页> 外文期刊>Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association >Reduced insulin-mediated glucose uptake by euglycemic clamp in offspring of patients with type 2 diabetes.
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Reduced insulin-mediated glucose uptake by euglycemic clamp in offspring of patients with type 2 diabetes.

机译：通过正常血糖钳夹降低2型糖尿病患者后代的胰岛素介导的葡萄糖摄取。

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Family studies point to an important genetic element in the genesis of type 2 diabetes. A variety of metabolic abnormalities have been documented in offspring of patients with type 2 diabetes. It has not been shown, however, at what age reduced insulin sensitivity is demonstrable using the sensitive the euglycemic clamp technique. To address this issue we screened 425 consecutive type 2 diabetic patients and examined all available (n = 48) normotensive, normoglycemic, non-smoking offspring (mean age 31.4+/-0.9 years) and compared them to 22 healthy offspring of non-diabetic parents (controls). The two groups were of similar age and BMI. Measurements in offspring and controls included baseline IRI, tissue glucose uptake (TGU, using euglycemic hyperinsulinemic clamp technique), and 24 hour ambulatory blood pressure (ABP). TGU was significantly (p < 0.001) lower in offspring of diabetic parents (338.8+/-19.9 (mol/kg/min) when compared to controls (516.6+/-22.2 micromol/kg/min). 24 h systolic ABP was significantly higher (p < 0.02) in propositi compared to controls (121.2+/-2.2 mm Hg and 113.8+/-1.7 mm Hg, respectively). No difference in triglycerides concentration was found. A borderline negative correlation was observed, however, between triglyceride levels and TGU (R = -0.48, p < 0.001). TGU was not related to the presence or absence of diabetic nephropathy in the parents. We conclude: Insulin resistance and various facets of the metabolic syndrome are demonstrable even at age 30 years in young non-obese, normotensive offspring of patients with type 2 diabetes. These disturbances are not related to the presence of microvascular complications in parents.
机译：家庭研究指出2型糖尿病的发生中重要的遗传因素。 2型糖尿病患者的后代中已记录了各种代谢异常。然而，尚未显示出使用敏感的正常血糖钳夹技术可证明在多大年龄时胰岛素敏感性降低。为了解决这个问题，我们筛选了425例连续的2型糖尿病患者，并检查了所有可用的（n = 48）血压正常，血糖正常，不吸烟的后代（平均年龄31.4 +/- 0.9岁），并将其与22位非糖尿病的健康后代进行了比较父母（控件）。两组的年龄和BMI相似。在后代和对照中的测量包括基线IRI，组织葡萄糖摄取（TGU，使用正常血糖高胰岛素钳夹技术）和24小时动态血压（ABP）。与对照组（516.6 +/- 22.2 micromol / kg / min）相比，糖尿病父母的TGU显着降低（p <0.001）（338.8 +/- 19.9（mol / kg / min）。24小时的收缩期ABP显着与对照组（分别为121.2 +/- 2.2 mm Hg和113.8 +/- 1.7 mm Hg）相比，propositi更高（p <0.02），甘油三酯浓度没有差异，但是甘油三酯之间存在临界负相关。水平和TGU（R = -0.48，p <0.001）。TGU与父母中是否存在糖尿病肾病无关。我们的结论是：即使在30岁时，胰岛素抵抗和代谢综合征的各个方面仍可证明2型糖尿病患者的年轻非肥胖，血压正常的后代，这些疾病与父母中存在微血管并发症无关。

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