Transcriptional targets in adipocyte biology.

Rosen E; Eguchi J; Xu Z

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Transcriptional targets in adipocyte biology.

机译：脂肪细胞生物学中的转录靶标。

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The global burden of metabolic disease demands that we develop new therapeutic strategies. Many of these approaches may center on manipulating the behavior of adipocytes, which contribute directly and indirectly to a host of disease processes including obesity and type 2 diabetes. One way to achieve this goal will be to alter key transcriptional pathways in fat cells, such as those regulating glucose uptake, lipid handling, or adipokine secretion. In this review, we look at what is known about how adipocytes govern their physiology at the gene expression level, and discuss novel ways that we can accelerate our understanding of this area.

机译：代谢性疾病的全球负担要求我们开发新的治疗策略。这些方法中的许多方法可能集中在操纵脂肪细胞的行为上，而脂肪细胞的行为直接或间接地导致了包括肥胖症和2型糖尿病在内的许多疾病的发生。实现此目标的一种方法是改变脂肪细胞中的关键转录途径，例如那些调节葡萄糖摄取，脂质处理或脂肪因子分泌的途径。在这篇综述中，我们将了解关于脂肪细胞如何在基因表达水平上调控其生理的已知知识，并讨论可以加快我们对该领域理解的新颖方法。

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《Expert opinion on therapeutic targets》 |2009年第8期|共12页
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Rosen E; Eguchi J; Xu Z;
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正文语种 eng
中图分类药学;
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1. Transcriptional targets in adipocyte biology. [J] . Rosen E, Eguchi J, Xu Z Expert opinion on therapeutic targets . 2009,第8期

机译：脂肪细胞生物学中的转录靶标。
2. SFRP5 is a target gene transcriptionally regulated by PPAR gamma in 3T3-L1 adipocytes [J] . Zeng Jun, Hu Jiongyu, Lian Yu, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2018,第期

机译：SFRP5是通过PPARγ在3T3-L1 adipocytes中转录的靶基因
3. Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish [J] . Zhonghua Zhao, Audrey Iyu, Xingang Wang, Biology Open . 2013,第11期

机译：斑马鱼中的Gli2a转录因子的目标失活和鉴定斑马鱼中的Gli2a转录因子的目标失活和鉴定斑马鱼中的Gli2a转录因子的失活和鉴定
4. cTAP: A Machine Learning Framework for Predicting Target Genes of a Transcription Factor using a Cohort of Gene Expression Data Sets [C] . Honglin Wang, Pujan Joshi, Seung-Hyun Hong, IEEE International Conference on Bioinformatics and Biomedicine . 2020

机译：CTAP：使用基因表达数据集的群组预测转录因子的靶基因的机器学习框架
5. Role of Wnt signaling and glycogen synthase kinase-3 beta in adipocyte biology. [D] . Silva, David A. 2007

机译：Wnt信号传导和糖原合酶激酶3β在脂肪细胞生物学中的作用。
6. Transcriptional targets in adipocyte biology [O] . Evan Rosen, Jun Eguchi, Zhao Xu -1

机译：在脂肪细胞生物学转录目标
7. A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology. [O] . Liron Levkovitz, Nir Yosef, Marvin C Gershengorn, 2010

机译：用于检测富集的转录因子结合位点的基于Hmm的新方法揭示了RUNX3作为胰腺癌生物学中的潜在靶标。

Transcriptional targets in adipocyte biology.

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