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MicroRNAs and multiple sclerosis: from physiopathology toward therapy

机译：MicroRNA和多发性硬化：从生理病理学到治疗学

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Introduction: MicroRNAs (miRNAs) are an emerging group of small noncoding RNAs that regulate gene expression posttranscriptionally, by targeting messenger RNAs (mRNAs) for translational repression or degradation. They have roles in multiple facets of immunity, from regulation of cell development to activation and function in immune responses. Recent evidence underlines an involvement of miRNAs in the pathogenesis of autoimmune diseases as well as multiple sclerosis (MS). Areas covered: In this review, the current knowledge of miRNA biogenesis, diverse roles of miRNAs in different cells that could be involved in the process of the disease, and their potential therapeutic applications are summarized. The authors searched MEDLINE and Science direct databases. Expert opinion: The miRNAs in central nervous system lesions and peripheral blood are potential biomarkers for diagnostic and prognostic use. Also, miRNA mimics, small-molecule inhibitors of specific miRNAs, and antisense oligonucleotides could be therapeutic weapons that facilitate us to combat the disease.
机译：简介：MicroRNA（miRNA）是一类新兴的小型非编码RNA，它们通过靶向信使RNA（mRNA）进行翻译抑制或降解来调控转录后的基因表达。它们在免疫的多个方面都有作用，从细胞发育的调控到免疫反应的激活和功能。最近的证据表明，miRNA参与了自身免疫性疾病以及多发性硬化症（MS）的发病机理。涵盖的领域：在本综述中，总结了miRNA生物发生的最新知识，miRNA在疾病过程中可能涉及的不同细胞中的不同作用及其潜在的治疗应用。作者搜索了MEDLINE和Science直接数据库。专家意见：中枢神经系统病变和外周血中的miRNA是潜在的生物标志物，可用于诊断和预后。同样，miRNA模拟物，特定miRNA的小分子抑制剂和反义寡核苷酸可能是促进我们与疾病作斗争的治疗武器。

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