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Targeting apicoplasts in malaria parasites

机译：靶向疟原虫中的原生质体

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Introduction: The relict plastid, or apicoplast, is a characteristic feature of Plasmodium spp. and reflects the unusual evolutionary origins of these parasites. The essential role this organelle plays in the life of the parasite, and its unusual, non-mammalian metabolism, make the apicoplast an excellent drug target. Areas covered: This review focuses on the biological role of the apicoplast in the erythrocytic life cycle and what that reveals about existing drug targets. We also discuss the future of the apicoplast in the development of anti-malarials, emphasizing those pathways with greatest potential as a source of novel drug targets and emphasizing the need to understand in vitro drug responses to optimize eventual use of these drugs to treat malaria. Expert opinion: More than a decade of research on the apicoplast has confirmed the promise of this organelle as a source of drug targets. It is now possible to rationally assess the value of existing drugs and new drug targets, and to understand the role these drugs can play in the arsenal of anti-malarial treatments.
机译：简介：残质质体（apicoplast）是疟原虫属的一种特征。并反映出这些寄生虫的异常进化起源。这种细胞器在寄生虫的生活中起着至关重要的作用，其异常的，非哺乳动物的新陈代谢使它们成为极好的药物靶标。涵盖的领域：这篇综述着重于无纺布生命周期中的apicoplast的生物学作用以及现有药物靶标的发现。我们还讨论了抗疟疾发展中apicoplast的未来，强调了具有最大潜力作为新型药物靶标来源的途径，并强调了需要了解体外药物反应以优化这些药物最终用于治疗疟疾的需求。专家意见：十年来对无纺布的研究证实了这种细胞器作为药物靶标来源的希望。现在可以合理地评估现有药物和新药物靶标的价值，并了解这些药物在抗疟疾治疗手段中的作用。

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