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首页> 外文期刊>Eye & contact lens >The disease burden of keratoconus in patients' lives: comparisons to a Japanese normative sample.
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The disease burden of keratoconus in patients' lives: comparisons to a Japanese normative sample.

机译：圆锥角膜在患者生活中的疾病负担：与日本规范性样本的比较。

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PURPOSE: Keratoconus is a chronic, noninflammatory, degenerative disease of the cornea that has an onset in young adulthood. The objective of this study was to evaluate vision-related quality of life (VR-QOL) in patients with keratoconus by using the Japanese version of the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25). METHODS: Forty-five patients diagnosed with keratoconus at the Keio University School of Medicine were enrolled. Patients were divided into three subgroups according to corrected visual acuity. Group A included patients whose best-corrected visual acuity was at least 20/20 in both eyes. Group B included patients with a best-corrected visual acuity of at least 20/20 in only one eye. Group C included patients whose best-corrected visual acuity was worse than 20/20 in both eyes. Thirty-six age-matched subjects were recruited as control subjects. The Japanese version of the NEI-VFQ-25 was administered to each subject. RESULTS: All NEI-VFQ-25 subscale scores were significantly lower (P<0.05) in patients with keratoconus than in the control subjects. Subscales evaluating general health, ocular pain, and vision-specific mental health showed particularly low values. Among patients with keratoconus, every subscale score other than color vision correlated with corrected visual acuity. CONCLUSIONS: The results support that and describe how multidimensional visual function and VR-QOL are impaired in patients with keratoconus, including those with normal visual acuity. Ophthalmologists and other clinicians should carefully evaluate and address the full range of quality of life issues that may affect patients with keratoconus.
机译：目的：圆锥角膜是一种慢性，非炎性，角膜退行性疾病，在成年后开始发病。这项研究的目的是通过使用日本版的《美国国家眼科研究所视觉功能问卷-25》（NEI-VFQ-25）来评估圆锥角膜患者的视觉相关生活质量（VR-QOL）。方法：入选庆应义University大学医学院诊断为圆锥角膜的45例患者。根据矫正视力将患者分为三个亚组。 A组包括两只眼睛的最佳矫正视力至少为20/20的患者。 B组包括只有一只眼睛的最佳矫正视力至少为20/20的患者。 C组包括双眼最佳矫正视力低于20/20的患者。招募36名年龄匹配的受试者作为对照受试者。日语版的NEI-VFQ-25被分配给每个受试者。结果：圆锥角膜患者的所有NEI-VFQ-25分量表评分均显着低于对照组（P <0.05）。评估总体健康状况，眼痛和视力特定的心理健康状况的分量表显示出特别低的价值。在圆锥角膜患者中，除色觉之外的每个子量表评分都与矫正视力相关。结论：结果支持并描述了圆锥角膜病患者，包括视力正常的多维视觉功能和VR-QOL受损。眼科医生和其他临床医生应仔细评估并解决可能影响圆锥角膜患者的生活质量问题。

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