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首页> 外文期刊>Gastrointestinal Endoscopy >Application of the newly developed stents in the treatment of benign cardia stricture: an experimental comparative study.
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Application of the newly developed stents in the treatment of benign cardia stricture: an experimental comparative study.

机译：新开发的支架在良性card门狭窄治疗中的应用：一项实验比较研究。

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BACKGROUND: Retrievable temporary stent placement has recently been suggested as a potential treatment for benign esophageal stricture. OBJECTIVE: To assess the efficacy of a newly designed cardia stent for the treatment of benign cardia stricture in a canine model compared with groups that received pneumatic dilation or standard esophageal stent insertion. DESIGN: Basic experimental study. SETTING: GI interventional center. PATIENTS: Forty-eight dog models were randomly divided into a control group (no stent insertion) (n=12), a pneumatic dilation group (PDG) (n=12), a standard esophageal stent group (SESG) (n=12), and a novel cardia stent group (NCSG) (n=12). INTERVENTIONS: Pneumatic dilation, standard esophagus stent, cardia stent. MAIN OUTCOME MEASUREMENTS: Lower esophageal sphincter pressures and the 5-minute barium height were assessed before and immediately after the procedure, after 1 week, and at 1-, 3-, and 6-month follow-up. Three dogs in each group were killed for histological examination. RESULTS: Stent insertion was tolerated by all dogs, with a lower migration rate in the NCSG (0% vs 41.7% in the SESG; P=.0373). At the 6-month follow-up, the lower esophageal sphincter pressure and 5-minute barium height values in the NCSG were still stable compared with those in the PDG and SESG (P<.05). Immunohistochemistry for mouse anti-proliferating cell nuclear antigen and alpha-smooth muscle actin revealed a stronger inflammatory reaction peak in the PDG than in the SESG and NCSG (P<.05). Collagen proliferation was most severe after 6 months in the PDG (P<.05). LIMITATIONS: Longer follow-up studies are required to assess whether the recurrence rate is lower because of less inflammation and scarring. CONCLUSIONS: The novel cardia stent was more effective than pneumatic dilation or a standard stent in this canine model.
机译：背景：最近有人提出可取下的临时性支架置入术可作为良性食管狭窄的潜在治疗方法。目的：与接受气动扩张或标准食管支架置入术的组相比，评估新设计的card门支架在犬模型中治疗良性card门狭窄的疗效。设计：基础实验研究。地点：胃肠道介入中心。患者：48只狗模型随机分为对照组（无支架插入）（n = 12），充气扩张组（PDG）（n = 12），标准食管​​支架组（SESG）（n = 12） ）和新型card门支架组（NCSG）（n = 12）。干预措施：气动扩张，标准食道支架，card门支架。主要观察指标：在手术前后，术后1周，以及1、3和6个月的随访中评估较低的食道括约肌压力和5分钟钡高度。每组三只狗被杀死进行组织学检查。结果：所有犬只均接受支架插入，NCSG中的迁移率较低（0％比SESG中的41.7％; P = .0373）。在6个月的随访中，与PDG和SESG相比，NCSG中较低的食管括约肌压力和5分钟钡高度值仍保持稳定（P <.05）。小鼠抗增殖细胞核抗原和α-平滑肌肌动蛋白的免疫组织化学显示，PDG中的炎症反应峰比SESG和NCSG中强（P <.05）。 PDG中6个月后胶原增生最严重（P <.05）。局限性：需要更长的随访研究来评估由于较少的炎症和疤痕而导致复发率是否较低。结论：在这种犬模型中，新型card门支架比气动扩张或标准支架更有效。

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